Disease-free survival in children with Ewing's sarcoma treated with radiation therapy and adjuvant four-drug sequential chemotherapy

Rosen, Gerald; Wollner, Norma; Tan, Charlotte; Wu, Saliangi; Hajdu, Steven I.; Cham, William; D’Angio, Giulio J.; Murphy, Michael

doi:10.1002/1097-0142(197402)33:2<384::aid-cncr2820330213>3.0.co;2-t

Cited by 226 publications

(69 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…13) Long-term survival can be expected in patients with Ewing's sarcoma when the tumor is radically excised, followed by radiation and chemotherapy. 24,25) This appears to be true for cranial Ewing's sarcoma as well. Distinction of primary from metastatic cranial Ewing's sarcoma is definitely important as the primary tumor can often be successfully managed by intensive therapy, including radical excision.…”

Section: Discussionmentioning

confidence: 90%

Primary Ewing's Sarcoma of the Occipital Bone. Case Report.

Erol

Özveren

Özercan

et al. 2001

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

A 17-year-old female presented with a very rare case of primary Ewing's sarcoma of the skull involving the occipitotemporal region. Systemic examination found no evidence of metastasis. The tumor was surgically removed, and the patient underwent radiotherapy and chemotherapy. Fourteen months after surgery there has been no recurrence of the tumor. Cranial primary Ewing's tumor has a good prognosis after radical surgery and adjuvant therapy.

show abstract

Section: Discussionmentioning

confidence: 90%

Primary Ewing's Sarcoma of the Occipital Bone. Case Report.

Erol

Özveren

Özercan

et al. 2001

Neurol. Med. Chir.(Tokyo)

View full text Add to dashboard Cite

show abstract

“…Between January 1975 and December 1984, effective chemotherapy protocols [14,15,16,24,25] were used and the survival rate increased to 46% (80/174); 67.2% of patients (117/174) underwent multidrug chemotherapy ( Table 2). The number of limb salvaging procedures (implantation of endoprostheses n=46, resections n=20) Between January 1985 and December 1994, primarily, the successful COSS 86 protocol [4] was applied in patients with osteosarcoma, while the CESS 86 and CESS 91 protocols [13] were used in those suffering from Ewing's sarcoma with a satisfactory outcome.…”

Section: Resultsmentioning

confidence: 99%

“…1a-c). (2) Period 2 (January 1975-December 1984), the period of effective multi-drug chemotherapy [6,8,14,15,16,25]. Surgical treatment consisted of amputation and resection-replantation [11,23] (Fig.…”

Section: Methodsmentioning

confidence: 99%

Advances in bone tumour treatment in 30 years with respect to survival and limb salvage. A single institution experience

Kotz

Dominkus

Zettl

et al. 2002

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

We analysed 721 patients with primary malignant bone tumours treated in a single institution with regard to diagnosis, treatment and prognosis. From 1965From to 1974 patients were treated, of whom 17% had no surgery, 36% underwent resection and 46% underwent amputation. Margins of resection were intralesional in 21%, 72% of patients received chemotherapy and overall survival rate was 24%. From 1975 to 1984, 174 patients were treated, of whom 12% had no surgery, 54% underwent limb salvage procedures and 34% underwent amputation or resection-replantation. Margins of resection were intralesional in 16% 67% of patients received chemotherapy and overall survival rate was 46%. From 1985 to 1994, 393 patients were treated, of whom 7% had no surgery, 77% underwent limb salvage procedures -mainly with endoprostheses -and 15% underwent amputation or resection-replantation. Margins of resection were intralesional in 12%, 68% of patients received chemotherapy and overall survival rate was 62%. Advancements in the treatment of primary malignant bone tumours justify limb salvage procedures in combination with highly effective polychemotherapy in specialised centres and has resulted in an overall survival rate of more than 60%.Résumé 721 malades porteur d'une tumeur osseuse maligne primitive traités dans une seule institution ont été analysés quant à diagnostic, traitement et pronostic. De 1965 à 1974, parmi 154 malades traités, 17% n'avaient aucune chirurgie, 36% ont eu une résection et 46% ont subi l'amputation. Les marges de résection étaient intralésionelles dans 21% des cas. 72% des malades ont reçu de la chimiothérapie. La survie totale était de 24%. De 1975 à 1984, parmi 174 malades traités, 12% n'avaient aucune chirurgie, 54% ont subi des procé-dures du sauvetage du membre et une amputation ou ré-section -replantation était exécuté dans 34%. Les marges de résection étaient intralésionelles dans 16% des cas. 67% des malades ont reçu de la chimiothérapie. La survie totale était 46%. De 1985De -1994 393 malades ont été traités de que 7% n'avaient aucune chirurgie, 77% ont subi des procédures du sauvetage du membre avec endoprosthèses et amputation ou résection -replantation a été exécuté dans 15%. Les marges de résection étaient intralesionales dans 12%. 68% des malades ont reçu la chimiothérapie. La survie totale était 62%. Les avancements dans le traitement de tumeurs osseuses malin primaires justifient des procédures du sauvetage du membre dans combinaison avec polychimiothérapie très efficace dans les centres spécialisés et ont résulté en un taux de la survie total de plus que 60%.

show abstract

“…At that time, prognosis for patients with Ewing's tumour was poor with few patients surviving to 5 years (Nesbit, 1976). However, there was some suggestion that by adding chemotherapy regimens, utilising vincristine, actinomycin-D, cyclophosphamide and doxorubicin, with radiotherapy resulted in improved outcome (Rosen et al, 1974). It had also been suggested that older age, pelvic site, presence of metastatic disease and high lactic dehydrogenase (LDH) adversely affect outcome (Pomeroy and Johnson, 1975).…”

mentioning

confidence: 99%

“…In addition, male gender and increasing tumour volume were identified as possible indicators of poor outcome. Treatment strategies including doxorubicin (Nesbit et al, 1981), vincristine, doxorubicin, cyclophosphamide and actinomycin-D (Rosen et al, 1974) and ifosfamide (Demeocq et al, 1984;Bramwell et al, 1985;Gobel et al, 1986;Magrath et al, 1986) were suggested as regimens that could result in a higher response rate for patients with Ewing's tumour.…”

mentioning

confidence: 99%

Establishing long-term survival and cure in young patients with Ewing's sarcoma

et al. 2004

View full text Add to dashboard Cite

This paper investigates the potential for long-term survivorship for young patients diagnosed with Ewing's sarcoma. Data are examined from two successive UKCCSG Ewing's Tumour studies (ET-1 and ET-2). Patients have been followed for up to 20 years. These studies had suggested that better 5-year survival with ET-2 over the earlier ET-1 was achieved by replacing cyclophosphamide by ifosfamide and increasing the dose of doxorubicin in a four-drug chemotherapy regimen. The updated hazard ratio, stratified for metastatic status at diagnosis, of 0.39 (95% confidence interval 0.12 -0.61) confirmed the advantage of the ET-2 regimen in terms of overall survival. Cure models, based on the Weibull distribution, suggested that factors for long-term survival in addition to presence of metastases were age, primary site of tumour and study. Modelling identified the proportion cured with the ET-2 protocol as best at 70% in those who are under 10 years with a nonpelvic primary site and without metastatic disease. This contrasts to only 13% cure in those with the corresponding adverse prognostic indicators. Additionally, the risk of death remains greatest but relatively constant over the first 2 years postdiagnosis, and then declines to a lower but constant value for the next 3 years before reaching the 'cure plateau' at about 5 years. This investigation suggests that 'cure' is possible for patients with Ewing's sarcoma. This is established at approximately 5 years post diagnosis and the proportion cured depends on the presence of metastases, pelvic site and age at diagnosis.

show abstract

Disease-free survival in children with Ewing's sarcoma treated with radiation therapy and adjuvant four-drug sequential chemotherapy

Cited by 226 publications

References 16 publications

Primary Ewing's Sarcoma of the Occipital Bone. Case Report.

Primary Ewing's Sarcoma of the Occipital Bone. Case Report.

Advances in bone tumour treatment in 30 years with respect to survival and limb salvage. A single institution experience

Establishing long-term survival and cure in young patients with Ewing's sarcoma

Contact Info

Product

Resources

About