Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis

Wong, Rebecca S. Y.

doi:10.1155/2019/5324170

Cited by 23 publications

(22 citation statements)

References 48 publications

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“…With the discovery of aspirin's mechanism of action by John Vane (Noble Prize 1982), understanding of NSAIDs increased over the years, thereby escalating the abilities to develop novel anti-inflammatory therapeutics. Owing to the analgesic, anti-pyretic, anti-inflammatory activities these drugs are extensively used in treating pain, fever and inflammation in rheumatic disorders, osteoarthritis and dysmenorrhoea [36,[43][44][45]. They are also implicated in sports medicine and popular among sports persons and soldiers [46][47][48][49].…”

Section: Therapeutic Uses and Repurposing Of Nsaidsmentioning

confidence: 99%

Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

Bindu

Mazumder

Bandyopadhyay

2020

Biochemical Pharmacology

1,065

519

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Owing to the efficacy in reducing pain and inflammation, non-steroidal anti-inflammatory drugs (NSAIDs) are amongst the most popularly used medicines confirming their position in the WHO's Model List of Essential Medicines. With escalating musculoskeletal complications, as evident from 2016 Global Burden of Disease data, NSAID usage is evidently unavoidable. Apart from analgesic, anti-inflammatory and antipyretic efficacies, NSAIDs are further documented to offer protection against diverse critical disorders including cancer and heart attacks. However, data from multiple placebo-controlled trials and meta-analyses studies alarmingly signify the adverse effects of NSAIDs in gastrointestinal, cardiovascular, hepatic, renal, cerebral and pulmonary complications. Although extensive research has elucidated the mechanisms underlying the clinical hazards of NSAIDs, no review has extensively collated the outcomes on various multiorgan toxicities of these drugs together. In this regard, the present review provides a comprehensive insight of the existing knowledge and recent developments on NSAID-induced organ damage. It precisely encompasses the current understanding of structure, classification and mode of action of NSAIDs while reiterating on the emerging instances of NSAID drug repurposing along with pharmacophore modification aimed at safer usage of NSAIDs where toxic effects are tamed without compromising the clinical benefits. The review does not intend to vilify these 'wonder drugs'; rather provides a careful understanding of their side-effects which would be beneficial in evaluating the risk-benefit threshold while rationally using NSAIDs at safer dose and duration.

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Section: Therapeutic Uses and Repurposing Of Nsaidsmentioning

confidence: 99%

Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

Bindu

Mazumder

Bandyopadhyay

2020

Biochemical Pharmacology

1,065

519

View full text Add to dashboard Cite

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“…The primarily euphoria of COX-2 inhibitors selectivity was short time studies because the indicating of serious cardiovascular complications risks during frequent therapy. Therefore, developing and design of novel active antiinflammatory and painkiller molecular agents with much more attractive safety profile is incurably presents a presumed significant challenge in this field of research 7 which presents with axial and nonaxial features, affecting structures within the musculoskeletal system, as well as other bodily systems. Both pharmacological and nonpharmacological therapeutic options are available for SpA.…”

Section: Introductionmentioning

confidence: 99%

Molecular drug design and docking study of novel n- substituted celecoxib derivatives as selective cyclooxygenase-2 inhibitors

Ezzat¹,

Razik²

2020

actapharm

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Celecoxib is one of the best potent nonsteroidal anti-inflammatory drug (NSAID) used as cyclooxygenase-2 (COX-2) selective inhibitor. For decades it effectively used in pain and inflammation treatment because the ability of reducing prostaglandin (PG) synthesis by obstruct the transformation of arachidonic acid to PGH2. But several serious side effects synchronized includes kidney failure, nausea, gastrointestinal tract bleeding, myocardial infarction, abdominal pain, and finally diarrhea. In this paper, a total of 155 Celecoxib derivatives were successfully docked inside crystal structure of cyclooxygenase-2 (COX-2) enzyme to estimate the potency of each derivative to bind inside active site. The highest twenty effective derivatives were recorded with docking score range of (-16.997 to-14.611) kcal/mol.

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“…Furthermore, the administration of glucocorticoid drugs on patients with COVID-19 did not provide adequate and acceptable results [ 218 ]. Nonsteroidal anti-inflammatory drugs (NSAIDs) have for a long time been considered effective therapies against inflammatory diseases [ 219 ]. To determine the efficacy of ibuprofen, a commonly prescribed NSAID, in COVID-19, a randomized phase 4 clinical study was applied in 230 severe COVID-19 patients to treat them with ibuprofen at a daily dose of 200 mg (NCT04334629).…”

Section: Therapeutic Interventions For Covid-19mentioning

confidence: 99%

Targeting Multiple Signal Transduction Pathways of SARS-CoV-2: Approaches to COVID-19 Therapeutic Candidates

et al. 2021

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Due to the complicated pathogenic pathways of coronavirus disease 2019 (COVID-19), related medicinal therapies have remained a clinical challenge. COVID-19 highlights the urgent need to develop mechanistic pathogenic pathways and effective agents for preventing/treating future epidemics. As a result, the destructive pathways of COVID-19 are in the line with clinical symptoms induced by severe acute coronary syndrome (SARS), including lung failure and pneumonia. Accordingly, revealing the exact signaling pathways, including inflammation, oxidative stress, apoptosis, and autophagy, as well as relative representative mediators such as tumor necrosis factor-α (TNF-α), nuclear factor erythroid 2-related factor 2 (Nrf2), Bax/caspases, and Beclin/LC3, respectively, will pave the road for combating COVID-19. Prevailing host factors and multiple steps of SARS-CoV-2 attachment/entry, replication, and assembly/release would be hopeful strategies against COVID-19. This is a comprehensive review of the destructive signaling pathways and host–pathogen interaction of SARS-CoV-2, as well as related therapeutic targets and treatment strategies, including potential natural products-based candidates.

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Disease-Modifying Effects of Long-Term and Continuous Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Spondyloarthritis

Cited by 23 publications

References 48 publications

Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective

Molecular drug design and docking study of novel n- substituted celecoxib derivatives as selective cyclooxygenase-2 inhibitors

Targeting Multiple Signal Transduction Pathways of SARS-CoV-2: Approaches to COVID-19 Therapeutic Candidates

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