Disease progression in murine systemic lupus erythematosus induced by consumption of amylase trypsin inhibitor (ATIs)

Zevallos, V; Weinmann‐Menke, Julia; Meineck, Myriam; Schuppan, Detlef

doi:10.1055/s-0036-1586827

Cited by 2 publications

(2 citation statements)

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“…Wheat ATIs are implicated in the pathogenesis of celiac disease as well as nonceliac wheat sensitivity [ 182 ]. Mice on a gluten-free diet show significantly attenuated clinical parameters of kidney dysfunction (proteinuria, haematuria, and hemoglobinuria) and serum inflammatory cytokines (IL-6 and TNF- α ) compared to mice on a gluten-containing diet [ 183 ]. Increased gluten intake is associated with increased concentrations of plasma inflammatory marker, α 2 -macroglobulin, in young adults without celiac disease [ 184 ].…”

Section: Diet Effect On Endothelial Function and Oxidative Stressmentioning

confidence: 99%

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

Man

Xia

2020

Oxidative Medicine and Cellular Longevity

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Healthy lifestyle and diet are associated with significant reduction in risk of obesity, type 2 diabetes, and cardiovascular diseases. Oxidative stress and the imbalance between prooxidants and antioxidants are linked to cardiovascular and metabolic diseases. Changes in antioxidant capacity of the body may lead to oxidative stress and vascular dysfunction. Diet is an important source of antioxidants, while exercise offers many health benefits as well. Recent findings have evidenced that diet and physical factors are correlated to oxidative stress. Diet and physical factors have debatable roles in modulating oxidative stress and effects on the endothelium. Since endothelium and oxidative stress play critical roles in cardiovascular and metabolic diseases, dietary and physical factors could have significant implications on prevention of the diseases. This review is aimed at summarizing the current knowledge on the impact of diet manipulation and physical factors on endothelium and oxidative stress, focusing on cardiovascular and metabolic diseases. We discuss the friend-and-foe role of dietary modification (including different diet styles, calorie restriction, and nutrient supplementation) on endothelium and oxidative stress, as well as the potential benefits and concerns of physical activity and exercise on endothelium and oxidative stress. A fine balance between oxidative stress and antioxidants is important for normal functions in the cells and interfering with this balance may lead to unfavorable effects. Further studies are needed to identify the best diet composition and exercise intensity.

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Section: Diet Effect On Endothelial Function and Oxidative Stressmentioning

confidence: 99%

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

Man

Xia

2020

Oxidative Medicine and Cellular Longevity

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“…A recent review reported that GFD is associated with a reduced risk of endothelial dysfunction and oxidative stress especially in CD individuals (327). Furthermore, an animal study also revealed that mice with GFD had reduced proinflammatory cytokines (Il-6 and TNF-α) (328). Hence, GFD is a promising approach to prevent GIT inflammation and dysbiosis and restores the integrity of epithelial barrier, thus indirectly influencing the prevention strategy in reducing risk toward other potential cardiocerebrovascular disease such as CSVD.…”

Section: Gluten-free Dietmentioning

confidence: 99%

Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease

Nassir

Ghazali

Hashim

et al. 2021

Front. Cardiovasc. Med.

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Cerebral small vessel disease (CSVD) represents a spectrum of pathological processes of various etiologies affecting the brain microcirculation that can trigger neuroinflammation and the subsequent neurodegenerative cascade. Prevalent with aging, CSVD is a recognized risk factor for stroke, vascular dementia, Alzheimer disease, and Parkinson disease. Despite being the most common neurodegenerative condition with cerebrocardiovascular axis, understanding about it remains poor. Interestingly, modifiable risk factors such as unhealthy diet including high intake of processed food, high-fat foods, and animal by-products are known to influence the non-neural peripheral events, such as in the gastrointestinal tract and cardiovascular stress through cellular inflammation and oxidation. One key outcome from such events, among others, includes the cellular activations that lead to elevated levels of endogenous cellular-derived circulating microparticles (MPs). MPs can be produced from various cellular origins including leukocytes, platelets, endothelial cells, microbiota, and microglia. MPs could act as microthrombogenic procoagulant that served as a plausible culprit for the vulnerable end-artery microcirculation in the brain as the end-organ leading to CSVD manifestations. However, little attention has been paid on the potential role of MPs in the onset and progression of CSVD spectrum. Corroboratively, the formation of MPs is known to be influenced by diet-induced cellular stress. Thus, this review aims to appraise the body of evidence on the dietary-related impacts on circulating MPs from non-neural peripheral origins that could serve as a plausible microthrombosis in CSVD manifestation as a precursor of neurodegeneration. Here, we elaborate on the pathomechanical features of MPs in health and disease states; relevance of dietary patterns on MP release; preclinical studies pertaining to diet-based MPs contribution to disease; MP level as putative surrogates for early disease biomarkers; and lastly, the potential of MPs manipulation with diet-based approach as a novel preventive measure for CSVD in an aging society worldwide.

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Disease progression in murine systemic lupus erythematosus induced by consumption of amylase trypsin inhibitor (ATIs)

Cited by 2 publications

References 0 publications

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function

Diets and Cellular-Derived Microparticles: Weighing a Plausible Link With Cerebral Small Vessel Disease

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