Stigma and discrimination toward people living with HIV are barriers to achieving the Joint United Nations Programme on HIV/AIDS 95-95-95 targets. Despite the high prevalence of negative attitudes toward people living with HIV in sub-Saharan Africa, factors associated with these attitudes are understudied. Using population-based HIV impact assessment (PHIA) data among adults aged 15-59 in Lesotho, Malawi, Tanzania, Zambia, and Zimbabwe, the relationship between HIV-related knowledge and discriminatory attitudes (DA) toward people living with HIV was assessed in a multivariable logistic regression model. Among 64,458 individuals, median age was 29 years (range 15-59), 51% were female, 63% rural, 65% self-reported HIVnegative, and 29% reported never testing for HIV. The study population was from Tanzania (44%), Zimbabwe (16%), Zambia (16%), Malawi (15%), and Lesotho (10%). Lesotho had the highest prevalence of insufficient HIV knowledge (70%), and Tanzania had the highest prevalence of DA (25%). Poor HIV prevention knowledge was significantly associated with having a DA, after adjustment for country, urbanicity, age, wealth quintile, education level household head HIV status, and self-reported HIV status (aOR: 2.65, 95% CI [2.47, 2.83]). Other variables that had a strong association with DA included a lack of formal education (aOR: 3.75, 95% CI [2.97, 4.74]), reporting of an "unknown" HIV status (aOR: 3.49, 95% CI [2.55, 4.78]), as well as being from Lesotho, Tanzania, Zambia, or Zimbabwe, from a rural area, aged 15-25 years, being HIV-negative, never testing for HIV, and lack of a head of household living with HIV ( p < .05). Inverse dose-response relationships were observed for education level and wealth quintile with DA (Table 2). Gender had no association with DA. Though this is not an intervention study, attention to factors associated with DA, especially modifiable factors such as HIV-related knowledge, can inform intervention development to globally reach the 95-95-95 targets.
Clinical Impact StatementThis study adds to the literature by providing an update on the state of discriminatory attitudes in several HIV-impacted countries using nationally representative populations. Individuals with lower HIV prevention knowledge, aged 15-25 years, of rural residence, the lowest wealth quintile, without formal education or with only primary education, without an HIV-positive head of household, and people who reported their HIV status as "unknown" or never being tested had significantly higher odds of holding a discriminatory attitude than their comparison groups. These individuals could be prioritized for intervention development, and further investigation of country-level causes of negative attitudes towards people living with HIV could be a focus for future research.