Disease-Specific and Common HLA and Non-HLA Genetic Markers in Susceptibility to Rheumatoid Arthritis, Type 1 Diabetes Mellitus and Multiple Sclerosis

Sjakste, Tatjana; Kalnina, Jolanta; Paramonova, Natalia; Ņikitina-Zaķe, Liene; Sjakste, Nikolajs

doi:10.4172/1747-0862.1000206

Cited by 1 publication

(1 citation statement)

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“…1 More than two hundred genes in the major histocompatibility complex (MHC) as well as non-MHC immune response genes are known to associate with SLE susceptibility. 2 Heterogenous human leukocyte antigen (HLA) susceptibility to SLE have been observed in different ethnic populations like Caucasoid, Chinese, Japanese etc. with commonest association of HLA-DRB1*15, DRB1*03, and DRB1*09.…”

Section: Introductionmentioning

confidence: 99%

Association of Human Leucocyte Antigen Class II, with viral load and immune response to Epstein–Barr virus in adult and pediatric Systemic lupus erythematosus patients

Das

Minz

Saikia

et al. 2022

Lupus

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Objective Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, which is known to be associated with HLA-DRB1 and Epstein–Barr virus (EBV) infection. In the Indian subcontinent where there is high seroendemicity of EBV, we postulated that the association of this virus in adult SLE (aSLE) and pediatric SLE (pSLE) patients would be different and differentially associate with the HLA-DRB1 susceptibility and protective genes. Methods A total of 109 aSLE, 52 pSLE, 215 adult healthy and 63 pediatric healthy controls were recruited. HLA-DRB1 genotyping by PCR-SSP, EBV load estimation by real-time PCR and antibody profiling (IgG & IgM) to EBV antigens by line blot assay were performed. Results DRB1*15 was found predominant in pSLE patients and DRB1*03 in aSLE patients. DRB1*15/X heterozygous was predominant in overall SLE patients, although disease severity, like hypocomplementemia, higher autoantibody levels and more organ involvement was observed in *15/*15 homozygous state. EBV strongly associated with pSLE patients showing higher percent of EA-D IgG ( p < 0.0001) and p22 IgG ( p = 0.035) along with higher viral load ( p = 0.001) as compared to healthy controls. In addition, the higher EBV DNA load significantly associated with anti-EA-D IgG ( p = 0.013) and DRB1*15/*15 ( p = 0.007) in pSLE patients as compared to aSLE patients. Conclusions This study therefore indicates that different HLA-DRB1 allotypes confer susceptibility to SLE in children and adults and disease may be triggered by increased EBV reactivation.

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Section: Introductionmentioning

confidence: 99%