Disease-specific health-related quality of life and its determinants in liver cirrhosis patients in Lithuania

Abstract

QOL was significantly impaired in all CLDQ domains in liver cirrhosis patients. Increase in severity of disease was the major factor associated with poorer QOL.

Translation and validation of the Hindi version of chronic liver disease questionnaire (CLDQ) for the assessment of health related quality of life in patient with chronic liver disease in India

“…The overall CLDQ score as well as the domain sub scores showed an inverse relationship with the disease severity. Similar pattern of association between Child Pugh Score and CLDQ has been demonstrated by other studies also 3,11,16,[23][24][25] . The post-hoc analysis revealed that the average and the sub scores of patients with Child C were significantly low than patients with both Child A and B, however most of the studies using CLDQ have not been able to differentiate between Child C and B 3,6,26 .…”

The factorial structure of the Chronic Liver Disease Questionnaire (CLDQ)

“…The original instrument was tested within a group of 133 patients and showed appropriate reliability and validity [3]. Since then, several studies have confirmed the ability of the CLDQ to discriminate between different stages of disease severity according to Child class [4][5][6][7][8][9][10]. Another study found that the CLDQ could discern between patients with and without comorbid diseases [11].…”

“…Furthermore, the CLDQ has proven to be responsive after liver transplantation [9,12] as well as after application of self-care and educational programs [13,14]. Between 2004 and 2006, a Thai [8], an Italian [11], a Spanish [9], and a Lithuanian [10] adaptation of the CLDQ were published. A German adaptation of the CLDQ was developed by Häuser et al in 2001.…”

Reviews on the Epidemiology, Quality of Life, and Management of Chronic Hepatitis B (CHB)

“…Previous studies suggested that biochemical markers, socio-demographic and psychosocial factors did affect HRQOL in patients with CLD but it has not been fully examined in Chinese CHB patients Bianchi et al, 2003;Hauser, Schnur, Steder-Neukamm, Muthny, & Grandt, 2004;Hussain et al, 2001;Marchesini et al, 2001;Sobhonslidsuk et al, 2006;Sumskiene, Sumskas, Petrauskas, & Kupcinskas, 2006;Younossi et al, 2001;Younossi et al, 2000). Disease severity, as measured by Child-Pugh scores or stage of CHB illness (asymptomatic, impaired liver function, cirrhosis and HCC), was one of the commonest factors that had a negative relationship with HRQOL Marchesini et al, 2001;Sobhonslidsuk et al, 2006;Sumskiene et al, 2006;Younossi et al, 2001;Younossi et al, 2000). However, some studies did not find any significant effect between HRQOL and disease severity (Hauser, Holtmann, & Grandt, 2004;Hauser, Zimmer, Schiedermaier, & Grandt, 2004).…”