Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease: A European population study

Dale, Maria; Maltby, John; Shimozaki, Steven S.; Cramp, Rebecca L.; Rickards, Hugh

doi:10.1016/j.jpsychores.2015.11.003

Cited by 34 publications

(15 citation statements)

References 48 publications

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“…This data renders a direct evidence that repeated stretches of the androgen receptor (CAG)n and (GGC)n microsatellite are potentially involved in the ligand-binding transactivation capacity. This is in line with the published data in Iranian [Zare-Karizi et al 2016] and European populations [Dale et al 2016]. Furthermore, the positive correlation among both trinucleotide repeats is in agreement with previous study [Tirabassi et al 2016].…”

Section: Correlation Of Sexual Performance and Elongated (Cag)n Repeatssupporting

confidence: 93%

Tri-nucleotide consortium of androgen receptor is associated with low serum FSH and testosterone in asthenospermic men

Khan¹,

Bhatti

Abbas³

et al. 2017

Systems Biology in Reproductive Medicine

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Section: Correlation Of Sexual Performance and Elongated (Cag)n Repeatssupporting

confidence: 93%

Tri-nucleotide consortium of androgen receptor is associated with low serum FSH and testosterone in asthenospermic men

Khan¹,

Bhatti

Abbas³

et al. 2017

Systems Biology in Reproductive Medicine

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“…Similar findings were found in a study with Huntington disease where disease stage predicted anxiety and depression; however, sex did not [71]. Multivariable logistic regression analyses identified the independent predictors for BSI global indices higher than the mean levels found in general population.…”

Section: Discussionsupporting

confidence: 82%

Psychopathological Dimensions in Portuguese Subjects with Transthyretin Familial Amyloid Polyneuropathy

et al. 2017

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Background: Transthyretin familial amyloid polyneuropathy (TTR-FAP) is a fatal, chronic, progressive disease. It is a rare hereditary amyloidosis, which manifests as a sensorimotor neuropathy and autonomic dysfunction. It begins during adulthood. Aims and Methods: Our aim is to evaluate psychopathological dimensions in a population attending a consultation center for TTR-FAP. Two hundred and nine subjects (symptomatic and asymptomatic carriers), 84 men and 127, women participated in the study. Most subjects were married (67.1%) and most of them were still working; 33% were retired from work or on a sick leave. A sociodemographic questionnaire and The Brief Symptom Inventory (BSI) were applied. Statistical analysis was performed (descriptive analysis, Mann-Whitney, Wilcoxon, and Spearman tests). Results: The Global Symptom Index (GSI) was significantly higher in patients (p = 0.001). Considering GSI, 32.7% of total subjects were above the median for general population. When subgroups were evaluated, 25.6% of symptomatic carriers, 26.3% of subjects without established diagnosis, and 39.1% of patients were above median. GSI was significantly higher in patients (p = 0.001). Some BSI dimensions were also significantly higher in the patient group (somatization, depression, anxiety, and psychoticism) when compared with carriers. Women scored higher than men. Sick women scored higher for all dimensions except somatization. Asymptomatic carriers scored statistically higher for phobic anxiety (p = 0.01), interpersonal sensitivity, anxiety, and depression. In patients, most dimensions and GSI (rho = 0.33, p = 0.002) had positive correlations with years of disease. Conclusions: TTR-FAP patients and carriers are a very vulnerable group for psychological distress and psychopathological problems. Women and patients are at higher risk.

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“…14 In addition, contrary to our data, sex was not described as a significant predictor of depressive symptoms, anxiety, or general distress in HD. 15 We observed that depressive symptoms became less severe over time in both male and female HD patients. Our results corroborate previous reports in which the proportion of HD patients endorsing significant depression diminished with disease progression.…”

Section: Discussionmentioning

confidence: 64%

Sex Differences in Huntington's Disease: Evaluating the Enroll‐HD Database

Hentosh

Zhu

Patino

et al. 2021

Movement Disord Clin Pract

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Background Identifying sex‐related differences is critical for enhancing our understanding of factors that may impact prognosis and advance treatments in Huntington's disease (HD). Objectives To investigate if sex‐related differences exist in clinical HD. Methods Longitudinal study of the Enroll‐HD database. Manifest HD patients were included in the analysis (N = 8401). Linear mixed models were used to assess motor, behavioral, and cognitive functioning over a series of four annual visits, and compared male and female HD gene carriers. Results HD patients showed significant sex‐dependent differences in motor, cognitive, and behavioral symptoms. Both sexes had worsened motor symptoms over the course of four visits, but there was a significant disparity between sexes, with females consistently presenting with more symptoms than males. For behavioral symptoms, specifically depressive symptoms, females had significantly more depressive symptoms, although self‐reported symptoms in both sexes became less severe throughout time. Conclusions Our analyses suggest that women have worse symptoms than men during the course of HD.

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Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease: A European population study

Cited by 34 publications

References 48 publications

Tri-nucleotide consortium of androgen receptor is associated with low serum FSH and testosterone in asthenospermic men

Tri-nucleotide consortium of androgen receptor is associated with low serum FSH and testosterone in asthenospermic men

Psychopathological Dimensions in Portuguese Subjects with Transthyretin Familial Amyloid Polyneuropathy

Sex Differences in Huntington's Disease: Evaluating the Enroll‐HD Database

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