Diseases of the Adrenal Glands

The Interrenal Syndrome in Childhood

“…The differential diagnosis of Goldstein et al (1946), Kepler and Keating (1941), Goldzieher (1945c), andSoffer (1946).…”

“…In these cases the only constant finding in the pituitary is a hyalinization of the cytoplasm of the basophil cells, described by Crooke (1935). Kepler (1945) considered these changes to be secondary to the adrenal hyperplasia, being in the nature of the effects of' depression of function of the basophil cells which were considered to secrete the adrenotropic agent. Marks et al (1940), in a review of the literature of adrenocortical obesity in children, quoted one case INTERRENAL SYNDROME as having hyaline changes in the basophil cells of the pituitary, though in their own case there was a slight increase in the number of acidophil as compared with the basophil cells.…”

The Medical Treatment of Essential Hypertension

“…~. Numerous cases exhibiting the character-IS~IC~of Cushing's syndrome but without pitUItary or adrenal cortical tumour have been described, and have been assumed to be due to the presence of cortical hyperplasia (Davis and Clark, 1950;Kepler and Keating, 1941. ) 4• Phaeochromocytoma of the adrenal me~ulla usually produces paroxysmal hypertensive attacks, accompanied by shivering and pallor, tachycardia, perspiration, nausea and cyanosis of extremities.…”