Diseases of the Blood Vessels

Braun‐Falco, Otto; Plewig, Gerd; Wolff, Helmut H.; Winkelmann, R. K.

doi:10.1007/978-3-642-97931-6_22

Cited by 5 publications

(2 citation statements)

References 228 publications

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“…As there is no ideal classification of SVV, in this study, patients were grouped based on the pathohistological findings of the biopsy of vasculitic skin changes: (1) patients in the florid phase of the disease; (2) patients in the active phase of the disease; and (3) patients in the regressive phase of the disease. The obtained distribution of the subjects, according to the phase of the disease, age and gender, is in agreement with the data from the literature [ 1 , 23 ]. The SVV was most common in adults with similar incidence in females and males in all three phases of the disease.…”

Section: Discussionsupporting

confidence: 90%

The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis

et al. 2021

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Small-vessel vasculitis (SVV) is the inflammation of the vessel wall that can result in hemorrhage and/or ischemia. Among the histological findings in SVV are increased infiltrating neutrophils, which, due to their oxidative burst and myeloperoxidase activity, release excessive reactive oxygen species, triggering a chain reaction of lipid peroxidation and yielding reactive aldehydes such as acrolein. The implication of oxidative stress in the pathogenesis of SVV was studied, focusing on acrolein immunohistochemistry in the affected skin vessels and systemic stress response. Samples from SVV patients and healthy subjects were collected and analyzed for total serum peroxides, total antioxidant capacity, inflammatory and immunological parameters, as well as for the presence of acrolein–protein adducts in the skin tissue specimens. The obtained data showed that systemic redox homeostasis and iron metabolism are altered in SVV patients. Possible biomarkers in the evaluation of oxidative status, disease activity and prevalence were indicated. Furthermore, a strong correlation between the accumulation of acrolein–protein adducts in the skin and the progression of the disease was revealed. Thus, the results of this study demonstrate that SVV is not only associated with systemic oxidative stress but also with tissue-specific oxidative stress that promotes acrolein formation and protein modification correlating with the severity of cutaneous vasculitis.

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Section: Discussionsupporting

confidence: 90%

The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis

et al. 2021

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“…[ 1 ] It has been described in patients with increased venous pressure and stasis caused by venous insufficiency, congenital/acquired arteriovenous anomalies, arteriovenous shunts and lower limb paralysis or amputation stumps. [ 2 3 4 ] Different names, like congenital dysplastic angiopathy, pseudo-Kaposi sarcoma, and acral capillary angiomatosis,[ 5 ] have been used. Mali et al coined the term “Acroangiodermatitis” that is favored in the recent literature.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous acroangiodermatitis

Kokenek-Unal¹,

Alper

Çoban

2015

Indian J Dermatol

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Acroangiodermatitis is a rare self-limited angioproliferative lesion which can be associated with congenital vascular malformations or acquired venous insufficiency. Despite of its benign character, differential diagnosis of this lesion is very important because it closely resembles Kaposi sarcoma. Here we present a 26-year-old male patient with unilateral, purplish-red colored papules on his right ankle which diagnosed as acroangiodermatitis and discuss histopathological features, differential diagnosis and treatment of this unusual condition.

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