2014
DOI: 10.1016/b978-0-444-53488-0.00033-x
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Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses

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Cited by 26 publications
(23 citation statements)
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“…It is not unprecedented for a viral disease with overt hemorrhagic signs to also affect the brain. Lassa virus, Junin virus, and other hemorrhagic arenaviruses enter the brain and cause neurological symptoms that can include encephalitis, hearing loss, and tremors [41,42]. Similar to our observations in CCHFV brain infection of SGM3 humanized mice, Junin virus also infects astrocytes, and neurodegenerative reactive astrogliosis may play a role in the pathogenesis of acute and late neurological symptoms in Junin virus infection [43][44][45][46].…”
Section: Discussionsupporting
confidence: 85%
“…It is not unprecedented for a viral disease with overt hemorrhagic signs to also affect the brain. Lassa virus, Junin virus, and other hemorrhagic arenaviruses enter the brain and cause neurological symptoms that can include encephalitis, hearing loss, and tremors [41,42]. Similar to our observations in CCHFV brain infection of SGM3 humanized mice, Junin virus also infects astrocytes, and neurodegenerative reactive astrogliosis may play a role in the pathogenesis of acute and late neurological symptoms in Junin virus infection [43][44][45][46].…”
Section: Discussionsupporting
confidence: 85%
“…However, investigating its role in MS is more difficult due to low titres and short presence of LCMV in the CSF. 131 In our opinion, this might indicate a "hit-and-run" mechanism. On the other hand, recent in silico predictions show high sequence and structural similarity between LCMV's nucleoprotein and specific myelin basic protein (MBP) residues.…”
Section: Lymphocytic Choriomeningitis Virus (Lcmv)mentioning
confidence: 87%
“…132 Murine models of chronic LCMV infection have given rise to two Nobel Prizes. 131 The virus is thought to activate microglia and astrocytes in the CNS via a TLR2-mediated cascade. 133 Moreover, LCMV blocks induction of type 1 interferon and consequential upregulation of HLA class II.…”
Section: Lymphocytic Choriomeningitis Virus (Lcmv)mentioning
confidence: 99%
“…Este fenotipo clínico, característico de las infecciones por LCMV, está mediado por anticuerpos y ocurre cuando los animales se infectan antes o inmediatamente después del nacimiento. La infección del timo resulta en el desarrollo de células T tolerantes al LCMV sin función efectora para destruir las células infectadas, producir citocinas y reclutar células mononucleares en el sitio de la replicación viral, lo cual genera incapacidad para eliminar el virus (34). Mientras esta reacción de los linfocitos T citotóxicos está deshabilitada, se producen anticuerpos antivirales que circulan en el suero y forman complejos inmunitarios (35) que no son detectados fácilmente con la prueba serológica empleada en este estudio, fenómeno que podría explicar el hecho de haber obtenido secuencias de LCMV a partir de varios ratones seronegativos en la prueba ELISA.…”
Section: Discussionunclassified