Diseases of the generative nail apparatus. Part I: Nail matrix

Nicolopoulos, Jenny; Goodman, Greg; Howard, Anne

doi:10.1046/j.1440-0960.2002.00567.x

Cited by 16 publications

(9 citation statements)

References 59 publications

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“…Periungual fibromas may exert pressure on the matrix to cause nail grooves, in much the same way as postulated for digital myxoid cysts 21, 22. However, we and others12 have observed nail grooves in TSC with no visible periungual fibroma.…”

Section: Discussionsupporting

confidence: 66%

“…It is not a specific finding, however, as longitudinal leukonychia is present inmost patients with Hailey -Hailey disease26, and white streaks together with red streaks are found in Darier disease 22, 27. Longitudinal leukonychiais a relatively uncommon finding in TSC, and its utility in diagnosis must take into account these other conditions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Acral lesions in tuberous sclerosis complex: Insights into pathogenesis

Aldrich¹,

Hong²,

Groves³

et al. 2010

Journal of the American Academy of Dermatology

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Acral lesions in tuberous sclerosis complex: Insights into pathogenesis

Aldrich¹,

Hong²,

Groves³

et al. 2010

Journal of the American Academy of Dermatology

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“…Subungual hyperkeratosis is associated with increased nail plate thickness due to nail bed or hyponychium hyperplasia caused by psoriasis, chronic focal inflammation, trauma to the nail, congenital ichthyosis, and onychomycosis (21)(22)(23). We observed that subungual hyperkeratosis appeared in 27.5% of patients with UC and in 27.3% of patients with CD.…”

Section: Discussionmentioning

confidence: 99%

Nail changes in patients with inflammatory bowel diseases

et al. 2016

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Background/aim: Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. To our knowledge, no studies to date pertain to the profile of nail changes in IBD, except for onychomycosis. We aimed to study the frequency and pattern of nail changes among patients with IBD and evaluate their potential relationships with several parameters in IBD. Materials and methods:The study included 73 patients with IBD and 51 healthy control subjects. Nails of both groups were examined for changes with regard to color, striations, texture, curvature of nail plates, dystrophy of nail plates, and pigmentation. Mycological examinations were performed when onychomycosis was suspected.Results: Nail changes were statistically higher in patients with IBD than in the control group (P = 0.001). The presence of onychomycosis was significantly more common in patients with IBD (P = 0.041). Subungual hyperkeratosis and brownish discoloration of the nail were the most common findings in patients with IBD. Conclusion:Our study is the first report showing all nail changes in IBD. Further studies with more subjects are needed to reveal more detailed information about nail changes in IBD.

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“…Systemic factors include old age, malnutrition, fever, and severe illness (i.e., mumps, acute febrile tuberculosis, typhoid and chronic nephrosis) (37)(38)(39)(40). Local factors include denervation, including median or ulnar nerve injury (41,42), nail bed injury (43), nail matrix injury (44), sympathetic dystrophy (45), relapsing polychondritis (46), and local infection. Some chemotherapeutic or immunosuppressive agents, such as methotrexate and azathioprine, have also been reported (47) to decrease nail growth.…”

Section: Discussionmentioning

confidence: 99%

Cessation of nail growth following Bajiaolian intoxication

Chou

Kao

et al. 2008

Clinical Toxicology

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Bajiaolian (Dysosma pleianthum), a species in the Mayapple family (Podophyllum pelatum), has been widely used as a traditional Chinese herbal medication for the remedies of snake bite, tumor growth, post-partum recovery, and acne. It has also been used in western medicine, especially topically for various skin lesions. Both oral ingestion and dermal application may result in severe toxicity. The clinical presentations reported after Bajiaolian poisoning include nausea, vomiting, diarrhea, abdominal cramps, tachycardia, orthostatic hypotension, paralytic ileus, urinary retention, hepatorenal dysfunction, leukocytosis followed by leukopenia, thrombocytopenia, prolonged areflexia, prolonged paraethesia and sensory ataxia, dizziness, fever, memory impairment, hallucinations, paranoia, convulsion, fainting, and coma. There are no previous reports in the literature about the cessation of nail growth as a clinical presentation following Bajiaolian poisoning. We present a case of nail growth that was halted for more than seven years after a single case of Bajiaolian poisoning.

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Diseases of the generative nail apparatus. Part I: Nail matrix

Cited by 16 publications

References 59 publications

Acral lesions in tuberous sclerosis complex: Insights into pathogenesis

Acral lesions in tuberous sclerosis complex: Insights into pathogenesis

Nail changes in patients with inflammatory bowel diseases

Cessation of nail growth following Bajiaolian intoxication

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