Diseases of the hair

Restrepo, Rodrigo; Calonje, Eduardo

doi:10.1016/b978-1-4160-5649-2.00022-6

Cited by 10 publications

(12 citation statements)

References 734 publications

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“…However, androgen levels in these women may be elevated or normal [44, 45]. It is estimated that FAGA occurs in only every fourth woman with signs of virilization and elevated levels of androgen [46, 47].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia

Urysiak-Czubatka¹,

Kmieć²,

Broniarczyk-Dyła³

2014

pdia

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IntroductionAndrogenetic alopecia (AGA) is the most common form of hair loss. Clinically observed hair loss is due to the continuous miniaturization of affected hair follicles. Genetic factors and androgenic factors especially dihydrotestosterone (DHT), which is a testosterone tissue metabolite, play major roles in the pathogenesis of AGA. However, expert opinions about the usefulness of DHT in the diagnosis of this type of alopecia are divided.AimTo evaluate the usefulness of DHT level in patients with androgenetic alopecia compared with the control group.Material and methodsThe study comprised 49 subjects: 19 women and 9 men with androgenetic alopecia. The control group consisted of 17 healthy women and 4 men without hair loss.ResultsIncreased serum concentrations of DHT were observed in patients with androgenetic alopecia (17 women, 5 men), but also in the control group. The differences in mean values of DHT were not significant according to the types of alopecia and the control group. Increased serum concentrations of DHT were not correlated with the advance of alopecia.ConclusionsDihydrotestosterone is the most influential androgen and seems to play a very important role in the pathogenesis of androgenetic alopecia. Based on the results of our study and others, the most important factors would appear to be the genetically-determined sensitivity of the follicles to DHT and their different reactions to androgen concentration.

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Section: Introductionmentioning

confidence: 99%

Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia

Urysiak-Czubatka¹,

Kmieć²,

Broniarczyk-Dyła³

2014

pdia

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“…Inflammatory infiltrate consists primarily of T lymphocytes and Langerhans cells, with occasional eosinophils, mast cells, and plasma cells [31,32]. An early and typical feature is the presence of eosinophils in stellae and within hair bulbs [29]. Anagen hairs cycle through catagen then into telogen.…”

Section: Histopathologymentioning

confidence: 99%

“…Biopsy should be taken from the periphery of the lesion as this is the site where the disease activity is found [28]. Horizontal sections will give a better representation of the histopathology especially in bulb infiltration than vertical sections [29].…”

Section: Diagnosismentioning

confidence: 99%

Alopecia Areata

Engın¹,

Oba²,

Tüzün³

2017

Hair and Scalp Disorders

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Alopecia areata is an organ-specific autoimmune disease targeting hair follicles. It causes nonscarring hair loss. The prevalence rate of the disease is approximately 1 in 1000 people worldwide. The condition is most commonly seen as circular areas of hair loss, but it may sometimes be as extensive as to involve the whole scalp or whole body. The complex pathophysiology of alopecia areata involves an autoimmune basis. Association of alopecia areata with other autoimmune diseases, such as thyroiditis and vitiligo, and the good response of patients to immunosuppressive treatment support an autoimmune etiology. Although some poor prognostic signs are defined, the course of the disease is unpredictable and the response to treatment can be variable. To date, there are neither preventive nor curative measures to deal with the condition. First-line therapy for patchy disease is topical and intralesional steroids, whereas extensive disease is conventionally managed with immunotherapy. New treatment agents, such as excimer laser, low-dose recombinant interleukin 2, Janus kinase inhibitors, and simvastatin/ezetimibe, are promising.

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“…Um sinal sugestivo é a presença de poucos fios terminais na linha de implantação dos cabelos. 6,7 O exame dermatoscópico é útil para o diagnóstico e na AFF revela, predominantemente, uma diminuição de óstios foliculares, escama e eritema perifolicular, além de capilares arboriformes. 41 As características histopatológicas da AFF são bastante semelhantes àquelas 58-91% dos casos.…”

Section: Etiologia E Patogênese Das Alopecias Cicatriciais (Ac)unclassified

“…Em negros, os pontos brancos podem estar presentes, visto que não o há destruição anexial no LPP. 41O exame laboratorial complementar mais importante é a imunofluorescência direta e a pesquisa de anticorpos para diferenciar esta doença do lúpus eritematoso discoide e do lúpus eritematoso sistêmico, respectivamente 6. Desde a descrição do LPP algumas variantes têm sido consideradas, com destaque para a AFF e para uma outra apresentação mais rara descrita por Piccardi, em 1913 e publicada por Graham Little, em 1915 levando o nome de ambos e caracterizada pela tríade: alopecia cicatricial do couro cabeludo, alopecia não cicatricial das regiões axilares e pubianas, e presença de pápulas foliculares ceratósicas agrupadas, lembrando líquen espinuloso ou ceratose pilar no tronco e extremidades 7.…”

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Análise comparativa das características clínico-patológicas e imunopatológicas do líquen plano pilar e da alopecia frontal fibrosante

Moure¹

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Diseases of the hair

Cited by 10 publications

References 734 publications

Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia

Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia

Alopecia Areata

Análise comparativa das características clínico-patológicas e imunopatológicas do líquen plano pilar e da alopecia frontal fibrosante

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