Diseases of the Mediastinum

Seaton, Douglas

doi:10.1002/9780470695999.ch49

Cited by 5 publications

(1 citation statement)

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“…Prognosis usually depends upon the clinical stage of the tumor. [ 6 ] However, aggressiveness of the thymoma also depends upon the appearance of the neoplastic epithelial cells and their numerical predominance over lymphocytes. [ 7 ] Hence, capsular invasion and adjacent structure involvement are more common in epithelial type and therefore malignant behavior.…”

Section: Discussionmentioning

confidence: 99%

Superior vena caval syndrome and ipsilateral pleural effusion: A rare presentation of anterior mediastinal thymoma

et al. 2014

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Incidence of thymic malignancies is very low. Thymoma, a tumor of thymus gland, is of epithelial origin and is most common anterior mediastinal tumor. In most cases, thymomas are localized and locally advanced thymomas may rarely present with superior vena caval obstruction (SVCO) and malignant pleural deposits. Microscopically, capsular invasion is noted in case of locally advanced thymomas, which behave like a malignant neoplasm. Complete surgical removal of the tumor along with intact capsule is the treatment modality of choice in case of localized tumors. Neoadjuvant radiotherapy (RT) and chemotherapy followed by surgical resection of residual tumor is useful in case of locally advanced tumors. RT is especially useful in case of SVCO to relieve the distressing respiratory symptoms. Here, we report a rare case of locally advanced thymoma, complicated by SVCO and ipsilateral pleural effusion in a 53-year-old male patient.

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Section: Discussionmentioning

confidence: 99%