In recent years, researchers have noted an increase in mortality from neurodegenerative diseases and a decrease in mortality from strokes. There have been no studies comparing mortality from these causes in the regions of the Russian Federation.Aim: comparative analysis of regional (age-) standardized death rate (SDR) among men and women from cerebrovascular diseases (CVD) and nervous system diseases (NSD) in 2013 and 2022 and discussion of factors influencing SDR.Materials and methods. Rosstat data obtained upon request were used. SDR was calculated using software (state registration number of computer program 216661114) using the European Standard Population using the direct standardization method per 100 thousand population; The average regional SDR values were calculated for the class of NSD and individual groups from this class, CVB (codes I60–69).Results. A decrease in the regional average SDR from CVD was revealed among men (218.09 ± 60.81 in 2013 and 159.41 ± 51.20 per 100 thousand people in 2022) and women (144.30 ± 39.33 and 103.51 ± 32.63 respectively) and the increase in SDR from LBP (19.77 ± 17.70 and 65.99 ± 56.67 for men, 10.99 ± 11.32 and 52.81 ± 46.13 for women). Only in 4 regions was there a decrease in SDR from both NSD and CVD in both men and women. The dispersion of regional SDRs from NSD and CVB in 2022 compared to 2013 increased by more than 10 times, which indicates a significant and growing regional variability of indicators. In the stroke group, the most significant decrease occurred from “Stroke not specified as hemorrhage or infarction” (code I64). The regional average contribution of acute stroke (codes I60–64) to the SCS from NSD and CVB (in total) decreased (in 2013 among women 51.57 ± 16.26 %, in 2022 33.96 ± 14.95 %; among men 54.0 ± 15.01 and 39.82 ± 14.26 respectively). Alzheimer’s disease makes a negligible contribution to mortality; In men in certain regions, alcohol-associated LBP is significant.Conclusions. Significant regional variability of SDR from individual groups of causes and a general trend towards a decrease in SDR from CVD and an increase in SDR from NSD were revealed, which is due to many factors. To eliminate the influence of different approaches to determining the cause of death, a unified protocol of criteria for their establishment is necessary.
