This report describes a case of unilateral optic disc oedema in a 54-year-old Maltese female. The most common causes for this appearance in this age group are the ischaemic optic neuropathies, specifically papillophlebitis and non-arteritic anterior ischaemic optic neuropathy (AION), and tumours of the orbit. The differential diagnosis of optic disc oedema is discussed and the decision process needed to reach a diagnosis is outlined.