Diseases of the Pituitary and Adrenal Gland

Swiet, Michael de

doi:10.1002/9780470752371.ch13

Cited by 3 publications

(9 citation statements)

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“…Unlike in hypopituitarism due to Sheehan's syndrome, that due to lymphocystic hypophysitis may or may not follow pregnancy, or overt postpartum haemorrhage. 2,3 Lymphocystic hypophysitis (LH) is a rare pituitary gland inflammatory disease of suspected autoimmune aetiology. 2,3,4,5,6,7,8,9 Most of the cases occur in young women during pregnancy or the first postpartum year.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Lymphocystic hypophysitis (LH) is a rare pituitary gland inflammatory disease of suspected autoimmune aetiology. 2,3,4,5,6,7,8,9 Most of the cases occur in young women during pregnancy or the first postpartum year. 3,4,5,6 It presents with varying degrees of hypopituitarism and often in association with autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

“…2,3,4,5,6,7,8,9 Most of the cases occur in young women during pregnancy or the first postpartum year. 3,4,5,6 It presents with varying degrees of hypopituitarism and often in association with autoimmune diseases. In this syndrome, in the early stage a mass lesion is often seen on the MRI or CT scan which when biopsied consist of lymphocystic infiltration.…”

Section: Introductionmentioning

confidence: 99%

“…In this syndrome, in the early stage a mass lesion is often seen on the MRI or CT scan which when biopsied consist of lymphocystic infiltration. 2,3 The mass being inflammatory in origin later disappears. The clinical feature is that of panhypopituitarism or in most cases partial hypopituitarism or isolated deficiency.…”

Section: Introductionmentioning

confidence: 99%

“…The clinical feature is that of panhypopituitarism or in most cases partial hypopituitarism or isolated deficiency. 2,3,6,7 This includes amenorrhea, infertility, weakness, cold intolerance, fever, confusion, nausea and vomiting, diarrhea, hypotension and hyperkalemia. We report a case of a Nigerian woman with partial hypopituitarism secondary to LH in whom a successful ovulation induction was followed by an uneventful pregnancy of a healthy baby following misoprostol induction of labour at term.…”

Section: Introductionmentioning

confidence: 99%

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Ovulation Induction, Pregnancy and Delivery in a Patient with Partial Hypopituitarism due to Lymphocystic Hypophysitis: A Case Report

Ezechi

Ezeobi

Nwokoro

1970

Nepal j. obstet. gynaecol.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ovulation Induction, Pregnancy and Delivery in a Patient with Partial Hypopituitarism due to Lymphocystic Hypophysitis: A Case Report

Ezechi

Ezeobi

Nwokoro

1970

Nepal j. obstet. gynaecol.

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Vomiting and hyponatraemia in pregnancy

George

Selvaraju²,

Reddy

et al. 2000

BJOG

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A 35 year old primigravida was admitted to hospital at 18 weeks of gestation with recurrent attacks of vomiting. Her symptoms first developed in the sixth week of pregnancy, and she had been admitted three times with a provisional diagnosis of hyperemesis gravidarium. On each occasion the w o r n was hyponatraemic (plasma sodium [119][120][121][122][123][124][125][126][127][128] mmol/L), with normal plasma potassium, urea, creatinine and glucose levels. During each admission she improved with anti-emetic drugs and intravenous normal saline and was then discharged. In the eight weeks before her pregnancy, the woman had experienced anorexia, weight loss and intermittent diarrhoea. On her fourth admission she appeared well, if slightly dehydrated, had a blood pressure of 100/80 mmHg with no postural hypotension and showed discolouration of skin and mucous membranes (ascribed initially to her Portuguese ancestry). Otherwise the clinical examination was normal. She was treated with intravenous normal saline, but despite this became hypotensive (blood pressure 80/40 mmHg) and remained hyponatraemic (plasma sodium 1OP-115 mmol/L). A presumptive diagnosis of Addison's disease was made. Blood was taken to estimate random cortisol and adrenocorticotrophic hormone levels, and she was treated with intravenous hydrocortisone. Her random serum cortisol concentration was 106 nrnoVL and adrenocorticotrophic hormone concentration was > 1500 ng/L, confinnng primary adrenal failure. The serum was strongly positive for 21-hydroxylase antibodies, suggesting auto-immune adrenalitis, the commonest cause of Addison's disease. Glutamic acid decarboxylase, thyroid peroxidase and thyroglobulin antibodies were also positive but glucose tolerance and thyroid function were normal. Following her intravenous steroid therapy the woman was given oral hydrocortisone and fludrocortisone and subsequently her blood pressure and plasma sodium concentration returned to normal, with restoration of her wellbeing. The remainder of her pregnancy was uneventful, and she was delivered at 41 weeks of a male infant weighing 2500 g. In herCorrespondence: Dr L. George, c/o Dr Peter's Secretary, Ward B7, University Hospital of Wales, Heath, Cardiff CF4 4XW, UK. 808 labour she was treated with 50 mg intravenous hydrocortisone eight-hourly and was re-started on her usual dose of oral hydrocortisone 24 hours after her delivery. Case report 2A 24 year old primigravida was admitted at 3 1 weeks of gestation with headache, nausea and vomiting for the previous two days. She had diabetes mellitus treated with insulin. On admission she was drowsy with no abnormal neurological signs and no abnormality on general physical examination. Her blood pressure was 115/80 d g . In view of drowsiness computed tomography and a lumbar puncture were performed, the results of which were normal. Her plasma sodium concentration was 136 mmol/L and potassium 3.8 mmol/L. Her diabetes was treated with intravenous soluble insulin and infusion of 5% dextrose.Her headache, nausea and vomiting p...

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Addison’s disease masquerading hyperemisis gravidarum

Pannila

Ransiri

Wijepala

et al. 2012

Sri Lanka J Obstet & Gynae

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Addison's disease is primary hypoadrenalism. It results from progressive destruction of the adrenals. We present a literature review and the case of a 24-year old lady presenting with repeated hospital admissions for 'hyperemesis grvidarum' since 10 weeks of POA. On clinical examination she was found to have a very low BMI with mucous membrane pigmentation and no other significant clinical findings. Biochemical tests confirmed the diagnosis of Addison's disease.

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Diseases of the Pituitary and Adrenal Gland

Cited by 3 publications

References 173 publications

Ovulation Induction, Pregnancy and Delivery in a Patient with Partial Hypopituitarism due to Lymphocystic Hypophysitis: A Case Report

Ovulation Induction, Pregnancy and Delivery in a Patient with Partial Hypopituitarism due to Lymphocystic Hypophysitis: A Case Report

Vomiting and hyponatraemia in pregnancy

Addison’s disease masquerading hyperemisis gravidarum

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