Diseases of the Thyroid Gland

Gargill, Samuel L.; Lesses, Mark Falcon

doi:10.1056/nejm194611142352005

Cited by 5 publications

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“…Thyrotoxic vomiting, however, was certainly known to earlier physicians, and Osler's Principles and Practice of Medicine [15], vividly described such a case. Cameron in 1945 knew it too [16], although he felt it a symptom of crisis or near crisis, as have others [17,18].…”

Section: Discussionmentioning

confidence: 89%

Nausea and Vomiting as Major Presenting Symptoms of Thyrotoxicosis

et al. 2018

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Thyrotoxicosis has a variety of presentations which depend on its severity and duration, as well as the age of the patient. Nausea and vomiting as major presenting symptoms of thyrotoxicosis are rarely reported. We report three patients with nausea and vomiting as major presenting symptoms of thyrotoxicosis, where two of the patients were extensively investigated, and thyrotoxicosis was not suspected until late in the disease. In reporting these patients we aim at drawing attention to these forgotten symptoms of thyrotoxicosis, and particularly to emphasize that, at times nausea and vomiting may be the only presenting features of thyrotoxicosis, leading to considerable difficulty in diagnosis. Moreover, these case reports give further support to the contention that thyroid studies should be carried out in border indications than conventionally accepted.

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Section: Discussionmentioning

confidence: 89%

Nausea and Vomiting as Major Presenting Symptoms of Thyrotoxicosis

et al. 2018

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“…15 Cameron in 1945 knew it too, although he felt it a symptom of crisis or near crisis, as have others. [16][17][18] Recent literature has suggested that vomiting may be more important as a cardinal symptom of thyrotoxicosis, and that it is not only seen in thyrotoxic storm but is part of a more prolonged chronic presentation. [4][5][6][7][8][9] In most of these cases the diagnosis was delayed because of the atypical presentation of thyrotoxicosis.…”

Section: Discussionmentioning

confidence: 99%

Nausea and vomiting as major presenting symptoms of thyrotoxicosis after bilateral adrenalectomy for Cushing's disease

et al. 2018

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Thyrotoxicosis has a variety of presentations which depend on its severity and duration, as well as the age of the patient. In elderly patients, thyrotoxicosis may present with a variety of nonspecific symptoms. Nausea and vomiting as major presenting symptoms of thyrotoxicosis have rarely been reported. Thyrotoxicosis after adrenalectomy in patients with Cushing's syndrome and normal thyroid function, or with autoimmune thyroid dysfunction has rarely been reported previously. We describe a very rare case of an elderly patient with hypothyroidism due to Hashimoto's thyroiditis who presented with persistent nausea and vomiting as major presenting symptoms of thyrotoxicosis, which developed after bilateral adrenalectomy for Cushing's disease. Similar case has not been reported previously. In reporting this patient we aim at drawing attention to these forgotten symptoms of thyrotoxicosis, nausea and vomiting, and to emphasize that, at times, these symptoms may be the only presenting features of thyrotoxicosis, leading to considerable difficulty in diagnosis. Furthermore, cessation of glucocorticoid excess may sometimes be accompanied with thyrotoxicosis.

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“…Liver damage has been reported after thiouracil therapy on several occasions (Livingstone, 1947; Sloan and Storr, 1944; Kahn and Stock, 1944; Gargil and Lesses, 1945; Holoubek et al, 1948). Goodwin (1948) reviewed the literature and investigated the effects of thiouracil therapy on liver function in eighty‐one cases of thyrotoxicosis over a period of twelve months.…”

Section: Figmentioning

confidence: 99%

THIOURACIL COMPOUNDS in the treatment of THYROTOXICOSIS

Goodwin

1949

Int J Clinical Practice

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Diseases of the Thyroid Gland

Cited by 5 publications

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Nausea and Vomiting as Major Presenting Symptoms of Thyrotoxicosis

Nausea and Vomiting as Major Presenting Symptoms of Thyrotoxicosis

Nausea and vomiting as major presenting symptoms of thyrotoxicosis after bilateral adrenalectomy for Cushing's disease

THIOURACIL COMPOUNDS in the treatment of THYROTOXICOSIS

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