Microgrids and hybrid renewable energy systems play a crucial role in today’s energy transition. They enable local power generation and distribution, reducing dependence on large centralized infrastructures, can operate independently or connected to a grid, and can provide backup power, thus increasing system resilience. In addition, they combine multiple renewable energy sources, such as solar, wind, hydro, and biomass, to maximize the efficiency and reliability of the supply, and are also adaptable to location-specific conditions, taking advantage of locally available energy resources and reducing the need for energy imports. Moreover, they contribute to decarbonization goals by offering a cleaner and more sustainable alternative. In this article, a documentary review is presented on the interaction of Homer Pro software 3.16.2 (July 2023), used for the design of hybrid renewable energy systems (HRES), with other methods of optimization or sizing. Allusion is made to the type of architecture in the most prominent clean and fossil source configurations, the levelized cost, net annual cost, and maintenance and capital investment cost. A comparison is made among the works reported in the last five years regarding the use of this software tool, based on load demand, geographical area, renewable energy sources, fossil sources, and objective functions, applied to the educational, rural, and industrial sectors. It is shown that India is one of the countries that has reported the most number of HRES techno-economic environmental analysis works, and that the case studies have focused approximately 47% on rural areas, 20% on educational agencies, 14% on commerce and industry, and 29% on urban buildings.