2024
DOI: 10.1101/2024.11.29.626057
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Disentangling cell type and state transcriptional programs

Jiayi Wang,
Helena L. Crowell,
Mark D. Robinson

Abstract: Single-cell omics approaches profile molecular constituents of individual cells. Replicated multi-condition experiments in particular aim at studying how the molecular makeup and composition of cell subpopulations changes at the sample-level. Two main approaches have been proposed for these tasks: firstly, cluster-based methods that group cells into (non-overlapping) subpopulations based on their molecular profiles and, secondly, cluster-free but neighborhood-based methods that identify (overlapping) groups of… Show more

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