Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data

Salvatore, Jessica E.; Lönn, Sara Larsson; Sundquist, Jan; Sundquist, Kristina; Kendler, Kenneth S.

doi:10.1177/0956797620931542

Cited by 6 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The associations observed for spousal FGRS-DUD were of similar magnitude to what was observed in our earlier study of the association between spousal parental history of AUD (i.e. a proxy for genetic loading) and the development of proband AUD during marriage [11]. In that report, spousal AUD predispositions (indexed with parental history) were associated with risk of AUD during marriage, OR = 1.66 (1.50, 1.84), which overlaps with the CIs for the spousal FGRS-DUD associations, OR males = 1.68 (1.50, 1.88), OR females = 1.35 (1.16, 1.56).…”

Section: Discussionsupporting

confidence: 85%

“…Therefore, it does not appear that the risk associated with a spouse's FGRS‐DUD is more simply explained as a rearing environmental effect. As a point of comparison, in our earlier effort to disentangle social genetic from rearing environmental effects for AUD using an extended‐family design [11], we found stronger evidence that a spouse's rearing environment accounted for the effects associated with their AUD predisposition (indexed by parental history) rather than the spouse's genetic makeup. The different patterns observed across these investigations of social genetic effects for AUD and DUD merit further investigation and may be attributable to the broader genetic risk captured by the FGRS‐DUD compared to the narrower parental history measure used in the study of AUD.…”

Section: Discussionmentioning

confidence: 83%

“…Individuals whose spouses carried the protective A allele of the ADH1B SNP rs1229984 drank less compared with those whose spouses were not carriers [9], and a spouse's genome‐wide polygenic predispositions were associated with BMI, smoking and drinking in a United States sample [10]. In contrast to these molecular genetic studies of drinking, we found that it was the spouse's having grown up with a parent with an alcohol use disorder (AUD), rather than the spouse's AUD genetic predisposition (as indexed by parental history), that was associated with proband risk for AUD [11]. This underscores the need for study designs that can disentangle social genetic effects from potentially confounding rearing environmental effects.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Social genetic effects for drug use disorder among spouses

et al. 2022

Self Cite

View full text Add to dashboard Cite

Aims Preclinical and human studies suggest that a social partner's genotype may be associated with addiction‐related outcomes. This study measured whether spousal genetic makeup is associated with risk of developing drug use disorder (DUD) during marriage and whether the risk associated with a spouse's genotype could be disentangled from potentially confounding rearing environmental effects. Design Univariable and multivariable logistic regression analyses. Setting Sweden. Participants Men and women born between 1960 and 1990 and in opposite‐sex first marriages before age 35 (n = 294 748 couples). Measurements Outcome was DUD diagnosis (inclusive of opioids, sedatives/hypnotics/anxiolytics, cocaine, cannabis, amphetamine and other psychostimulants, hallucinogens, other drugs of abuse and combinations thereof) obtained from legal, medical and pharmacy registries. The focal predictor was family genetic risk scores for DUD (FGRS‐DUD), which were inferred from diagnoses in first‐ through fifth‐degree relatives and weighted by degree of genetic sharing. FGRS‐DUD were calculated separately for each partner in a couple. Findings Marriage to a spouse with a high FGRS‐DUD was associated with increased risk of developing DUD during marriage, ORmales = 1.68 (95% CI = 1.50, 1.88) and ORfemales = 1.35 (1.16, 1.56), above and beyond the risk associated with one's own FGRS‐DUD. The risk associated with a spouse's FGRS‐DUD remained statistically significant after covarying for parental education. As indicated by a series of null interaction effects, there was no evidence that the risk associated with a spouse's FGRS‐DUD differed depending on whether the spouse was DUD‐affected, probands' probable contact with in‐laws and whether the spouse was raised by his/her biological parents or in another home. Conclusions There is relatively robust evidence that a person's risk for developing drug use disorder is associated with the genetic makeup of the person's spouse.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Social genetic effects for drug use disorder among spouses

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although social genetic effects have been established for numerous types of animals (Ellen et al 2014 ; Nielsen et al 2014 ; Baud et al 2017 ), trees (Brotherstone et al 2011 ), and bacteria (Lee et al 2010 ), and are sometimes found to be even stronger than direct genetic effects (Baud et al 2017 ), they were until recently virtually ignored in studies on human genetics (but see these recent studies; Brunello et al 2020 ; Das 2019 ; Harris et al 2018 ; Kong et al 2018 ; Laidley et al 2019 ; Liu 2018 ; Salvatore et al 2020 ; Sotoudeh et al 2019 ; Xia et al 2021 ). Because married/cohabiting people are exposed to their partner’s behavior (ego’s environment), which is partly driven by the partner’s genes, we may be able to detect social genetic effects.…”

Section: Introductionmentioning

confidence: 99%

Partners in Health: Investigating Social Genetic Effects Among Married and Cohabiting Couples

Otten

Mandemakers

2023

Behav Genet

View full text Add to dashboard Cite

Partners resemble each other in health behaviors and outcomes such as alcohol use, smoking, physical activity, and obesity. While this is consistent with social contagion theory suggesting partner influence, it is notoriously difficult to establish causality because of assortative mating and contextual confounding. We offer a novel approach to studying social contagion in health in long-term partnerships by combining genetic data of both partners in married/cohabiting couples with longitudinal data on their health behaviors and outcomes. We examine the influence of the partner’s genetic predisposition for three health outcomes and behaviors (BMI, smoking, and drinking) among married/cohabiting couples. We use longitudinal data from the Health and Retirement Study and the English Longitudinal Study of Ageing with data on health outcomes and genotypes for both partners. Results show that changes over time in BMI, smoking, and drinking depend on the partner’s genetic predispositions to these traits. These findings underline the importance of people’s social surroundings for their health and highlight the potential of targeting health interventions at couples.

show abstract

Meso Level

2021

Dynamic Pathways to Recovery From Alcohol Use Disorder

View full text Add to dashboard Cite

show abstract

Disentangling Social-Genetic From Rearing-Environment Effects for Alcohol Use Disorder Using Swedish National Data

Cited by 6 publications

References 24 publications

Social genetic effects for drug use disorder among spouses

Social genetic effects for drug use disorder among spouses

Partners in Health: Investigating Social Genetic Effects Among Married and Cohabiting Couples

Meso Level

Contact Info

Product

Resources

About