The study presents an application of Latent Profile Analysis to sustain the existence of different profiles of meaning-making (i.e., the process of searching and finding meaning in life) within the late adolescent’s population, and to investigate the role of resilience in predicting profiles’ belonginess. 943 Italian senior high-school students (52% females) were clustered into two adaptive profiles, highly-engaged (high presence, average search) and balanced (average presence and search), and two maladaptive profiles, frustrated (average presence, high search) and disengaged (low presence and search). A multinomial logistic regression revealed that adolescents with robust resilience skills were more likely to show adaptive profiles, and less likely to fall into the disengaged group, suggesting that individuals with higher resilience are more prone to engage in search for meaning even when they perceive a lack of presence of meaning. Findings contribute to a nuanced understanding of meaning-making, calling the development of personalized interventions to foster adolescents’ ability to navigate life challenges during their transition toward adulthood.