Disentangling the Association between ADHD and Alcohol Use Disorder in Individuals Suffering from Bipolar Disorder: A Systematic Review and Meta-Analysis

Bartoli, Francesco; Callovini, Tommaso; Calabrese, Angela; Cioni, Riccardo; Riboldi, Ilaria; Crocamo, Cristina; Carrà, Giuseppe

doi:10.3390/brainsci12010038

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…Our network analysis also revealed a weak connection between ADHD symptoms and PLEs. These observations are consistent with those obtained by previous studies showing that a diagnosis of ADHD is highly comorbid with other mental disorders [47][48][49]. It has also been found that a diagnosis of ADHD in childhood might predict the development of psychosis in adulthood [50].…”

Section: Discussionsupporting

confidence: 92%

Dimensions of psychopathology associated with psychotic-like experiences: Findings from the network analysis in a nonclinical sample

Rejek,

Misiak

2023

Eur. Psychiatr.

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Background Psychotic-like experiences (PLEs) are associated with a variety of psychopathological symptoms. However, it remains unknown which dimensions of psychopathology are most closely related to the occurrence of PLEs. In this study, we aimed to analyze the association of PLEs with various domains of psychopathology. Methods A total of 1100 nonclinical adults (aged 18–35 years, 51.4% females) with a negative history of psychiatric treatment were surveyed. Assessment of psychopathology was performed using self-reports. Symptoms associated with PLEs were explored as continuous variables and based on clinically relevant thresholds using two separate network analyses. Results In both network analyses, PLEs were directly connected to obsessive-compulsive disorder (OCD) symptoms, manic symptoms, depressive symptoms, and attention-deficit/hyperactivity disorder (ADHD) symptoms. Anxiety symptoms were associated with PLEs only in the network based on threshold scores. Importantly, edge weight for the connection of PLEs and OCD symptoms was significantly higher compared to edge weights of all other direct connections of PLEs with psychopathology in both networks. Edge weight for the connection between PLEs and manic symptoms was significantly higher compared to edge weights for direct connections of PLEs with depressive and ADHD symptoms in the network based on continuous scores of psychopathological symptoms. Edge weights of direct connections of PLEs with depressive, anxiety, and ADHD symptoms did not differ significantly in both networks. Conclusions Our findings indicate that PLEs are associated with multiple domains of psychopathology. However, these phenomena are most strongly associated with OCD symptoms regardless of their severity threshold.

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Section: Discussionsupporting

confidence: 92%

Dimensions of psychopathology associated with psychotic-like experiences: Findings from the network analysis in a nonclinical sample

Rejek,

Misiak

2023

Eur. Psychiatr.

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“…As a consequence, ADHD is often untreated in individuals with BD, with no more than 10% of subjects being properly diagnosed and receiving specific treatment for ADHD (Bond et al, 2012). Moreover, although recent systematic data attempted to clarify the epidemiological impact of ADHD in BD (Bartoli et al, 2022;Sandstrom et al, 2021;Schiweck et al, 2021), findings on possible sociodemographic and clinical correlates of this comorbidity are sparse and somehow inconsistent. The identification of factors associated with comorbid ADHD could be useful to clarify if these subjects might represent a clinical subpopulation with specific unmet needs, thus requiring tailored treatments.…”

Section: Introductionmentioning

confidence: 99%

Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis

Bartoli

Callovini

Cavaleri

et al. 2022

Aust N Z J Psychiatry

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Objective: Attention deficit hyperactivity disorder is a frequent comorbid condition in adults with bipolar disorder. We performed a meta-analysis aimed at assessing sociodemographic and clinical correlates of attention deficit hyperactivity disorder in bipolar disorder. Method: We searched main electronic databases up to June 2021. Random-effects meta-analyses, with relevant meta-regression and quality-based sensitivity analyses, were carried out to estimate the association between attention deficit hyperactivity disorder and putative correlates, grading the quality of evidence. Results: We included 43 studies, based on 38 independent samples. Attention deficit hyperactivity disorder participants were more likely to be males (odds ratio = 1.46; p < 0.001) and unemployed (odds ratio = 1.45; p = 0.045), and less likely to be married (odds ratio = 0.62; p = 0.014). They had an earlier onset of bipolar disorder (standardized mean difference = −0.36; p < 0.001); more mood episodes (standardized mean difference = 0.35; p = 0.007), particularly depressive (standardized mean difference = 0.30; p = 0.011) and mixed (standardized mean difference = 0.30; p = 0.031) ones; higher odds of using antidepressants (odds ratio = 1.80; p = 0.024) and attempted suicides (odds ratio = 1.83; p < 0.001) and lower odds of psychotic features (odds ratio = 0.63; p = 0.010). Moreover, they were more likely to have generalized anxiety disorder (odds ratio = 1.50; p = 0.019), panic disorder (odds ratio = 1.89; p < 0.001), social phobia (odds ratio = 1.61; p = 0.017), eating disorders (odds ratio = 1.91; p = 0.007), antisocial personality disorder (odds ratio = 3.59; p = 0.004) and substance (odds ratio = 2.29; p < 0.001) or alcohol (odds ratio = 2.28; p < 0.001) use disorders. Quality of the evidence was generally low or very low for the majority of correlates, except for bipolar disorder onset and alcohol/substance use disorders (high), and suicide attempts (moderate). Conclusion: Comorbid bipolar disorder/attention deficit hyperactivity disorder may have some distinctive clinical features including an earlier onset of bipolar disorder and higher comorbid alcohol/substance use disorder rates. Further research is needed to identify additional clinical characteristics of this comorbidity.

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“…ADHD has a negative impact on the lives of affected children, resulting in poor educational and work attainment, risk-taking behaviours, and unsatisfactory relationships (3,4,5,6). Furthermore, signi cant comorbidity between ADHD and other mental illnesses has been reported, particularly for mood disorders, anxiety disorders, drug and alcohol use disorders, and autistic spectrum disorders (7,8,9). Although the de nite cause of ADHD is unknown, complex interactions between genetic and environmental risk factors are responsible and play a signi cant role, with a heritability rate of about 70-80% (10).…”

Section: Introductionmentioning

confidence: 99%

Complete Blood Count Inflammatory Ratios in Attention Deficit Hyperactivity Disorder Children

Afify,

kamel,

Ali

2024

Preprint

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Background Attention deficit hyperactivity disorder (ADHD) is considered the most common neuropsychiatric disorder in children. Many researchers have suggested that changes in pro-inflammatory and anti-inflammatory cytokines could play a role in the pathogenesis of ADHD. We aimed in this study to evaluate the relationships between the CBC inflammatory markers (NLR, MLR, PLR, and MPV) and the severity of attention deficit hyperactivity disorder symptoms in children. Method: This study was a cross-sectional case-control study carried out on 80 ADHD children and 40 apparently healthy children as the control group. A complete blood count was obtained (white blood cell (WBC), neutrophil count, lymphocyte count, monocyte count, eosinophil and basophil counts, platelets, and mean platelet volume (MPV). Based on these counts, the neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and monocyte lymphocytic ratio were calculated. Results: CBC inflammatory ratios (NLR, MLR, and PLR) were considerably higher among children with ADHD than in the control group; moreover, a significant positive correlation was observed between the CBC inflammatory ratios (neutrophil/lymphocyte, monocyte/lymphocyte) and ADHD symptoms severity assessed by Conner's parent rating scale scores (total ADHD score, hyperactivity, impulsivity, and inattention scores). Conclusions: The results of our study proved that inflammation plays a significant role in the intricate pathophysiology of ADHD and suggest that CBC inflammatory ratios can be used as an indicator for ADHD severity. This is easily obtainable and reliable in evaluating the role of inflammation in ADHD etiology.

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Disentangling the Association between ADHD and Alcohol Use Disorder in Individuals Suffering from Bipolar Disorder: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 57 publications

Dimensions of psychopathology associated with psychotic-like experiences: Findings from the network analysis in a nonclinical sample

Dimensions of psychopathology associated with psychotic-like experiences: Findings from the network analysis in a nonclinical sample

Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis

Complete Blood Count Inflammatory Ratios in Attention Deficit Hyperactivity Disorder Children

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