Dishevelled-1 (Dvl-1) Protein: a Potential Participant of Oxidative Stress Induced by Selenium Deficiency

Zhao, Hua; Sun, Meina; Li, Meng-di; Li, Fenglan

doi:10.1007/s12011-013-9859-5

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Moreover, the deficiency of T cell also exhibits altered bacteria ( 59 ). As reported, Disheveled 1 (Dvl-1) is an important protein of the Wnt/β-catenin pathway ( 60 ), which controls the proliferation of T cell progenitors and regulates T cell development and Treg cell activation ( 61 – 63 ). In Dvl-1 knockout mice, the gut bacterial composition is altered through the promotion of opportunistic pathogen growth, such as Helicobacter mastomyrinus , and hinderance of commensal bacteria growth ( 64 ).…”

Section: The Crosstalk Between Intestinal Bacteria and Mucosal Immunementioning

confidence: 99%

Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk

et al. 2018

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The intestine is the shared site of nutrient digestion, microbiota colonization and immune cell location and this geographic proximity contributes to a large extent to their interaction. The onset and development of a great many diseases, such as inflammatory bowel disease and metabolic syndrome, will be caused due to the imbalance of body immune. As competent assistants, the intestinal bacteria are also critical in disease prevention and control. Moreover, the gut commensal bacteria are essential for development and normal operation of immune system and the pathogens are also closely bound up with physiological disorders and diseases mediated by immune imbalance. Understanding how our diet and nutrient affect bacterial composition and dynamic function, and the innate and adaptive status of our immune system, represents not only a research need but also an opportunity or challenge to improve health. Herein, this review focuses on the recent discoveries about intestinal bacteria–immune crosstalk and nutritional regulation on their interplay, with an aim to provide novel insights that can aid in understanding their interactions.

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Section: The Crosstalk Between Intestinal Bacteria and Mucosal Immunementioning

confidence: 99%

Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk

et al. 2018

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“…In patients with transmural MI, maximum DVL-1 values were recorded at the level of 3400-3440 pg/mL (Figure 1). The analysis of the serum level of DVL-1 with clinical and laboratory data in patients with coronary artery disease made it possible to establish statistically significant direct correlations between DVL-1, total cholesterol (p = 0.008) and LDL (p = 0.006), as well as the presence of a direct relationship with levels of β-catenin (p < 0.001) and WIF-1 (p < 0.001), indicating the important role of DVL-1 as an integrator of canonical and noncanonical WNT signaling [11].…”

Section: Resultsmentioning

confidence: 99%

Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease

M.O.

2023

Med. immunol.

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In recent years, researchers’ attention has been directed to the WNT signaling pathway study, which regulates embryogenesis processes and is involved in pathological condition development. The role of morphogenic proteins of WNT signaling pathway in the cardiovascular pathology genesis is practically not clear. The research aim was a comprehensive study of the main proteins of WNT signaling pathway (β-catenin, sclerostin, GSK-3α, GSK-3β, WIF-1 and DVL-1) in the blood serum of 353 patients with coronary artery disease acute forms who were treated at the Orel regional vascular center from 2019 to 2021, and 50 healthy individuals. A comprehensive analysis included an assessment of clinical, laboratory and instrumental parameters in the framework of current clinical guidelines, as well as an immunological examination to determine the morphogenic proteins of WNT signaling by enzyme immunoassay. The results showed a wide variability in the values of morphogenic proteins of WNT signaling pathway in the patient’s blood serum. The levels of β-catenin, WIF-1 and DVL-1 significantly exceeded those obtained in healthy individuals, while the concentrations of sclerostin and GSK-3β did not differ significantly from them. The level of GSK-3α of patients was twice lower than in healthy individuals. The highest sclerostin concentrations were found in patients with existing calcification of the aortic valve leaflets and aortic walls. Acute coronary syndrome unfavorable course was observed in patients with both extremely high and extremely low WIF-1 levels. Significant correlations were established between the level of morphogenic proteins of WNT signaling pathway and lipid metabolism, as well as myocardial remodeling. The obtained data on changes in the protein production of WNT signaling pathway allow us to expand our understanding of the molecular aspects of the immunopathogenesis of myocardial remodeling in coronary artery disease, increase the predictive potential for cardiovascular disease diagnosis and determine the vector for further development of cardioimmunology determination.

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The role of heat shock proteins in oxidative stress damage induced by Se deficiency in chicken livers

Liu

et al. 2014

Biometals

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Selenium (Se) is an essential dietary trace element, which acts as an antioxidant. Heat shock proteins (HSPs) are a family of intracellular proteins whose synthesis is greatly increased upon exposure of cells to environmental stressors including oxidative metabolites, heavy metals, amino acid analogues and so on. However, little is known about the role of HSPs in oxidative stress damage induced by Se deficiency in the chicken liver. The aim of this study was to investigate the effects of Se deficiency on the expression levels of HSPs (Hsps27, 40, 60, 70, and 90) and oxidative indexes in the chicken liver. A total of 300 1-day-old sea blue white laying hens were divided into two groups (n = 150/group), and each of those groups was randomly divided into groups so that the trials were conducted in triplicate. The Se-deficient group (-Se) was fed a Se-deficient corn-soy basal diet (the Se content was 0.02 mg/kg); the Se-adequate group as control (+Se) was fed the same basal diet supplemented with Se at 0.2 mg/kg (sodium selenite). The liver tissue was collected and examined for pathological observations, oxidative indexes, mRNA and protein levels of HSPs genes at 15, 25, 35, 45, 55 and 65 days old. The histopathological analysis showed that liver tissues were injured seriously in the Se-deficient group. The oxidative indexes data showed that the malondialdehyde (MDA) level increased and the activity of L-glutathione (GSH) and glutathione peroxidase (GSH-Px) in the chicken liver decreased in Se-deficient group (p < 0.05). Additionally, the mRNA levels of HSPs (27, 40, 60, 70, and 90) increased significantly (p < 0.05) in the Se-deficient group compare to the corresponding control group. Meanwhile, the protein expression of HSPs (60, 70, and 90) also increased significantly (p < 0.05) in the Se-deficient group. These results suggested that oxidative stress and the levels of HSPs expression levels in chicken liver can be influenced by dietary Se deficiency. And HSPs played an important role in the protection of the liver after oxidative stress due to Se deficiency.

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Dishevelled-1 (Dvl-1) Protein: a Potential Participant of Oxidative Stress Induced by Selenium Deficiency

Cited by 4 publications

References 35 publications

Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk

Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk

Role of morphogenic proteins of the WNT signaling pathway in coronary artery disease

The role of heat shock proteins in oxidative stress damage induced by Se deficiency in chicken livers

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