Dishevelled: An emerging therapeutic oncogene in human cancers

Alshahrani, Shadia Hamoud; Rakhimov, Nodir; Rana, Arti; Alsaab, Hashem O.; Hjazi, Ahmed; Adile, Mohaned; Abosaooda, Munther; Abdulhussien Alazbjee, Adeeb Abdulally; Alsalamy, Ali; Mahmoudi, Reza

doi:10.1016/j.prp.2023.154793

Cited by 2 publications

(1 citation statement)

References 107 publications

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“…In addition, the expression levels of Wnt3a and β-catenin were detected in cells with DKK1 knockdown. β-catenin can transfer into the nucleus to affect the transcription of target genes ( 47 ). Therefore, in addition to showing that DKK1 knockdown upregulates β-catenin expression, it would also be interesting to investigate whether β-catenin is also activated by DKK1 knockdown.…”

Section: Discussionmentioning

confidence: 99%

Role of prognostic gene DKK1 in oral squamous cell carcinoma

Liu,

Wei,

Wang

et al. 2023

Oncol Lett

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Oral squamous cell carcinoma (OSCC) is one of the most common squamous cell carcinomas of the head and neck. The morbidity and mortality rates of OSCC have increased in recent years. However, the pathogenesis of this disease remains unknown. The present study aimed to identify predictive biomarkers and therapeutic targets for OSCC. Bioinformatics screening of differentially expressed genes in OSCC was performed based on data from The Cancer Genome Atlas and Gene Expression Omnibus databases. Dickkopf Wnt signaling pathway inhibitor 1 (DKK1) was identified to be associated with survival, tumor immunity and DNA repair in OSCC. Furthermore, the effects of DKK1 were evaluated by the knockdown of DKK1 in two OSCC cell lines. The proliferation, clonogenicity, migration and invasion of the cells were assessed in vitro using Cell Counting Kit-8, colony formation, wound healing and Transwell assays, respectively, and were found to be inhibited by DKK1 knockdown. The present study suggests that DKK1 may be used in the prognosis of patients with OSCC and that targeting DKK1 is a potential strategy for OSCC therapy.

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Section: Discussionmentioning

confidence: 99%

Role of prognostic gene DKK1 in oral squamous cell carcinoma

Liu,

Wei,

Wang

et al. 2023

Oncol Lett

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Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling

Wang,

Zhu,

Wen

et al. 2024

Cells

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Dishevelled (DVL) proteins precisely control Wnt signaling pathways with many effectors. While substantial research has advanced our understanding of DVL’s role in Wnt pathways, key questions regarding its regulatory mechanisms and interactions remain unresolved. Herein, we present the recent advances and perspectives on how DVL regulates signaling. The experimentally determined conserved domain structures of DVL in conjunction with AlphaFold-predicted structures are used to understand the DVL’s role in Wnt signaling regulation. We also summarize the role of DVL in various diseases and provide insights into further directions for research on the DVL-mediated signaling mechanisms. These findings underscore the importance of DVL as a pharmaceutical target or biological marker in diseases, offering exciting potential for future biomedical applications.

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Dishevelled: An emerging therapeutic oncogene in human cancers

Cited by 2 publications

References 107 publications

Role of prognostic gene DKK1 in oral squamous cell carcinoma

Role of prognostic gene DKK1 in oral squamous cell carcinoma

Structural and Functional Insights into Dishevelled-Mediated Wnt Signaling

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