Disinfection of viruses with cold atmospheric‐pressure plasmas: Sources, mechanisms, and efficacy

Abstract

In recent years, the outbreaks of viral diseases have urgently demanded effective virus disinfection techniques. Among them, the use of cold atmospheric‐pressure plasma (CAP) is one of the most promising approaches. CAP generates electric fields, charged particles, reactive oxygen and nitrogen species, and ultraviolet. CAP can effectively inactivate various viruses in a short period, whether they are on surfaces, in water, or in aerosols, without significantly raising the substrate temperature. This review highlights that the simultaneous action of physical and chemical means is the key mechanism of CAP in virus inactivation. It systematically summarizes the characteristics of plasma devices suitable for different application scenarios and further points out the opportunities and challenges faced by plasma virus inactivation technology.

Molecular mechanism of cleavage of SARS-CoV-2 spike protein by plasma generated RONS

“…Cold atmospheric pressure plasma (CAP) is a complex mixture composed of reactive oxygen nitrogen species (RONS) (e.g., O, OH, H 2 O 2 , NO, NO 2 , ONOO − ), ultraviolet light (UV), electrons, ions, and electric fields [14,[18][19][20]. Current experimental detection methods primarily demonstrate the ability of Cold Atmospheric Plasma (CAP) to eliminate bacteria, fungi, viruses, and other microorganisms [21,22]. Additionally, some studies have explored the impact of nitro-oxidative stress on membranes and proteins [23][24][25].…”