Disintegration performance of renal multivitamin supplements

Stamatakis, Mary K.; Meyer-Stout, Paula Jo

doi:10.1016/s1051-2276(99)90004-3

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…However, the usefulness of these standards for nutrients not dependent on acid solubility for absorption (eg, calcium) has been questioned (27). The failure of US marketed products to meet USP dissolution standards was reported for a prenatal MVM (22), folic acid in prenatal MVMs (49,50), and renal MVMs (51). Similar failures of dissolution and disintegration were reported for MVMs marketed in Canada as compared with USP standards (52), for folic acid-containing products marketed in the United Kingdom as compared with British Pharamcopoieal standards (53), and for iron-containing products in Sweden (54).…”

Section: Testing Of Bioavailabilitymentioning

confidence: 99%

Multivitamin and multimineral dietary supplements: definitions, characterization, bioavailability, and drug interactions

Yetley

2007

The American Journal of Clinical Nutrition

162

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Although multivitamins, multiminerals, and similar terms (eg, multis or multiples) are commonly used, they have no standard scientific, regulatory, or marketplace definitions. Thus, multivitamins-multiminerals refers to products with widely varied compositions and characteristics. Multivitamin-multimineral composition databases use label values as surrogates for analyzed values. However, actual vitamin and mineral amounts often deviate from label values. Vitamin and mineral bioavailability for dietary supplements also lacks a standard scientific and regulatory definition and validated in vitro and animal models that accurately reflect human bioavailabilities. Systematic information on the bioavailability and bioequivalence of vitamins and minerals in marketed products and on potential drug interactions is scarce. Because of limited information on product characteristics, our ability to directly compare results across studies, estimate changes in usage patterns or intakes over time, and generalize from published results to marketed products is problematic.

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