Disintegration Properties and Drug Release Profiles of Sodium Alginate Films Modified with Additives

Murata, Yoshifumi

doi:10.31031/rdms.2017.02.000529

Cited by 2 publications

(1 citation statement)

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“…When FDs prepared with water-soluble polymers, such as Alg-Na, are placed in a small amount of liquid, such as saliva, they quickly disintegrate and release the incorporated drug. The disintegration profiles of FDs differ between species [5]. FDs prepared with polysaccharides are useful for the treatment of localized problems in the oral cavity and to simplify the administration of drugs to patients [6].…”

Section: Introductionmentioning

confidence: 99%

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2018

RDMS

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A film dosage form (FD) incorporating an antifungal agent, miconazole, was prepared with sodium alginate for the treatment of Candida infections. To ensure the safety of oral administration, FD was modified with additives, such as alginate hydrolysate, to control the drug dissolution rate. A soft film with a thickness of approximately 70µm was obtained and each FD was sufficiently strong to be applied by hand. FD immediately swelled in limited dissolution medium and then disintegrated to release the incorporated drug. The drug dissolution rate was controlled by the amount of additive in the film base solution. FD prepared with sodium alginate and the hydrolysate is useful for the treatment of oral candidiasis as the dosage form can be administered into the oral cavity to act directly on the affected site.

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Section: Introductionmentioning

confidence: 99%