Abstract:To improve university and commercial ties with industry, many universities operate a technology transfer office (TTO) as a vehicle to support the creation of spin-off companies. Run effectively, the TTO can define roles and responsibilities, structures and processes that support the creation and development of new ventures. The challenge for universities is to create TTOs with the right skill set. This paper aims to analyze the TTO activities to support transforming research outputs into commercialization in the context of the University of Agricultural Sciences and Veterinary Medicine from Cluj-Napoca, Romania (UASVMCN). Throughout this paper, different commercialization channels, the roles of technology transfer offices and multiple associative structures are further discussed with a special focus on agricultural open innovations and technologies. This study contributes to sustainable development of both Academia and agricultural Industry research, development and commercialization activities by illustrating current innovation and technology transfer activities produced by UASVMCN and its own TTO as a catalyst entity, a new model in Romania, so that the Academia-TTO-Economy partners association draw a functional and productive triple helix. In order to assess the sustainability of using the above-mentioned TTO, the methodological tools involving analysis are implemented. Finally, this paper states that correct operating of a university TTO is a real opportunity for technology transfer, both from the perspective of an alternative to research funding or entrepreneurship, and from the cultural perspective of the university correlation to the current trends in research, innovation and technology transfer, on a unique and entrepreneurial European market.