Disorder of Red Blood Cells: Anemias

Naeim, Faramarz

doi:10.1016/b978-0-12-370607-2.00023-5

Cited by 2 publications

(4 citation statements)

References 273 publications

(341 reference statements)

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Section: Introductionmentioning

confidence: 99%

“…Nutritional anemia is a prevalent health burden that affects individuals across all ages, with higher vulnerability observed among young children, women, and older adults. 1,2 Anemia is characterized by a low number of healthy circulating red blood cells (RBCs) or insufficient amount of hemoglobin (Hb) to carry oxygen. 2,3 Micronutrients, such as vitamins (A, B, C) and minerals (iron, zinc, iodine, calcium), play diverse and essential roles in the body, including proper growth, development, and blood formation.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Anemia is characterized by a low number of healthy circulating red blood cells (RBCs) or insufficient amount of hemoglobin (Hb) to carry oxygen. 2,3 Micronutrients, such as vitamins (A, B, C) and minerals (iron, zinc, iodine, calcium), play diverse and essential roles in the body, including proper growth, development, and blood formation. 4 Inadequate intake of these micronutrients, particularly iron, folate, and vitamin B 12 , is considered the primary contributing factor to anemia.…”

Section: Introductionmentioning

confidence: 99%

“…Iron deficiency (ID) is the most common cause of nutritional anemia, followed by deficiencies in folate and vitamin B 12 . 2,6,7 Developing nations experience the greatest impact, characterized by a prevalence exceeding 60% and estimated rates of 47.4%, 41.8%, and 30.2% among young children, pregnant women, and women of reproductive age, respectively. 6,8 A nationwide study conducted in four regions of Saudi Arabia unveiled a significant prevalence of anemia, with rates ranging from 16.5% to 41.3% among children, 7.2% to 16.5% among adult males, and 10.8% to 23.5% among adult females.…”

Section: Introductionmentioning

confidence: 99%

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Assessing Nutritional Anemia Among University Students in Jazan, Saudi Arabia: A Public Health Perspective

Hakami,

Dobie,

Alneami

et al. 2024

JBM

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Background Nutritional anemia is a significant public health concern worldwide, particularly affecting young adults and children in Saudi Arabia, where inadequate nutrition is considered a primary contributing factor. This study aims to (i) examine the levels of serum iron, folate, and vitamin B 12 in young adult students, with a focus on identifying any deficiencies and their association with anemia; (ii) explore the prevalence of mixed-deficiency anemia resulting from deficiencies in serum iron, folate, and vitamin B 12 (iii) explore how sociodemographic characteristics and dietary habits influence serum iron, folate, and vitamin B 12 levels. Materials and Methods This cross-sectional study encompassed 158 young adult students at Jazan University, Saudi Arabia. Blood samples were collected following a comprehensive questionnaire addressing sociodemographic and health characteristics. These samples were analyzed for complete blood count, serum iron, folate, and vitamin B 12 levels. Results The findings of this study revealed a significant decrease in serum iron levels, with 70.6% of males and 88% in females exhibiting reduced level. Additionally, low levels of folate were observed in 4% of the study population, while deficiency in vitamin B 12 was found in 2.2% of the study population. However, the simultaneous presence of low serum iron levels along with deficiencies in folate or vitamin B 12 was not observed in the study participants. Conclusion The study indicates that there is a high incidence of low serum iron and ferritin levels among university students in Saudi Arabia, which poses a considerable public health concern. Conversely, the prevalence of folate and vitamin B 12 deficiencies among the students was comparatively low, and notably, there were no cases where these deficiencies were observed alongside iron deficiency.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessing Nutritional Anemia Among University Students in Jazan, Saudi Arabia: A Public Health Perspective

Hakami,

Dobie,

Alneami

et al. 2024

JBM

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Mechanical Characterization of Human Red Blood Cells Under Different Osmotic Conditions by Robotic Manipulation With Optical Tweezers

Tan

Sun

Wang³

et al. 2010

IEEE Trans. Biomed. Eng.

145

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The physiological functions of human red blood cells (RBCs) play a crucial role to human health and are greatly influenced by their mechanical properties. Any alteration of the cell mechanics may cause human diseases. The osmotic condition is an important factor to the physiological environment, but its effect on RBCs has been little studied. To investigate this effect, robotic manipulation technology with optical tweezers is utilized in this paper to characterize the mechanical properties of RBCs in different osmotic conditions. The effectiveness of this technology is demonstrated first in the manipulation of microbeads. Then the optical tweezers are used to stretch RBCs to acquire the force-deformation relationships. To extract cell properties from the experimental data, a mechanical model is developed for RBCs in hypotonic conditions by extending our previous work , and the finite element model is utilized for RBCs in isotonic and hypertonic conditions. Through comparing the modeling results to the experimental data, the shear moduli of RBCs in different osmotic solutions are characterized, which shows that the cell stiffness increases with elevated osmolality. Furthermore, the property variation and potential biomedical significance of this study are discussed. In conclusion, this study indicates that the osmotic stress has a significant effect on the cell properties of human RBCs, which may provide insight into the pathology analysis and therapy of some human diseases.

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Disorder of Red Blood Cells: Anemias

Cited by 2 publications

References 273 publications

Assessing Nutritional Anemia Among University Students in Jazan, Saudi Arabia: A Public Health Perspective

Assessing Nutritional Anemia Among University Students in Jazan, Saudi Arabia: A Public Health Perspective

Mechanical Characterization of Human Red Blood Cells Under Different Osmotic Conditions by Robotic Manipulation With Optical Tweezers

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