Disordered Convolution Region of P(VDF-TrFE) Piezoelectric Nanoparticles: The Core of Sono–Piezo Dynamic Therapy

Abstract

The recent focus on P(VDF-TrFE) material in biomedical engineering stems from its outstanding mechanical properties and biocompatibility. However, its application in sono−piezo dynamic therapy (SPDT) has been relatively unexplored. In this study, we developed composite piezoelectric nanoparticles (rPGd NPs@RGD) based on recrystallized P(VDF-TrFE) particles, which offer dual capabilities of MRI imaging and targeted treatment for brain gliomas. SEM observations of P(VDF-TrFE) particles in the disordered convolution region (DCR) revealed recrystallization, representing the polymer chain structure and particle polarity. In comparison to nonrecrystallized nanoparticles, rPGd NPs@RGD exhibited remarkable stability and biocompatibility. Under ultrasound excitation, they generated significantly higher levels of reactive oxygen species, effectively inhibiting tumor cell proliferation, invasion, and migration. rPGd NPs@RGD demonstrated excellent MRI imaging capabilities and antitumor activity in U87 tumor-bearing mice. This study highlights the remarkable SPDT abilities of the developed nanoparticles, attributed to the microscopic morphological changes in the DCR that increase the nanoparticle's polarity and thus boost its potential for SPDT. This research opens new possibilities for utilizing P(VDF-TrFE) materials in advanced biomedical applications.

Ultrasonic-responsive piezoelectric stimulation enhances sonodynamic therapy for HER2-positive breast cancer

“…2 I), thus accounting for their stable particle size maintained at approximately 270 nm during storage for 1 to 3 weeks at 4 °C (Figure S4 b). Additionally, our separate study has also corroborated that following crystal structure remodeling, the P(VDF-TrFE) particles exhibit stabilized particle sizes of around 200 nanometers, particularly in the DMEM culture medium, owing to their enhanced hydrophilicity [ 31 ].…”

Recent advancements in bio-based dielectric and piezoelectric polymers and their biomedical applications

“…However, until recently, their biodegradability and biocompatibility in antitumor applications were not investigated. [149][150][151][152] Deng et al 153 developed a novel ultrasound-activated PLBSIEbased tumor/wound unified therapeutic platform, by copolymerizing lactic acid, butanediol, sebacic acid, and itaconic acid. Their elastomer demonstrated outstanding piezoelectric performance and high stretchability, and the separated carrier could react with water to generate highly cytotoxic reactive oxygen species (ROS), contributing to effectively killing tumor cells and eliminating bacteria through piezoelectric therapy.…”

“…However, until recently, their biodegradability and biocompatibility in antitumor applications were not investigated. 149–152…”