1983
DOI: 10.1097/00007890-198305000-00010
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Disordered Salivary Immunoglobulin Secretion and Sodium Transport in Human Chronic Graft-Versus-Host Disease

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Cited by 89 publications
(42 citation statements)
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“…19,[23][24][25][26][27][28][29] In 281 adult BMT recipients, Clark et al 24 found that chronic GVHD was a highly significant risk factor for the development of airflow obstruction. Airflow obstruction may be an indirect consequence of chronic GVHD via oesophagitis 30 with aspiration, sicca syndrome with Ig A deficiency, 31,32 and pulmonary infections due to immunosuppression. 28 However, lung epithelial cells may also be a direct cellular target of GVHD.…”
Section: Discussionmentioning
confidence: 99%
“…19,[23][24][25][26][27][28][29] In 281 adult BMT recipients, Clark et al 24 found that chronic GVHD was a highly significant risk factor for the development of airflow obstruction. Airflow obstruction may be an indirect consequence of chronic GVHD via oesophagitis 30 with aspiration, sicca syndrome with Ig A deficiency, 31,32 and pulmonary infections due to immunosuppression. 28 However, lung epithelial cells may also be a direct cellular target of GVHD.…”
Section: Discussionmentioning
confidence: 99%
“…One study where whole salivary analysis of patients with chronic oral GVHD was performed showed increased concentrations of sodium, albumin, and IgG, and reduced secretory IgA and inorganic phosphates (Izutsu et al, 1983a). However, when compared with patients who had undergone BMT, but did not develop chronic GVHD, the only differences were elevated sodium and decreased secretory IgA levels in whole saliva.…”
Section: (B) Oral Presentationmentioning
confidence: 99%
“…However, when compared with patients who had undergone BMT, but did not develop chronic GVHD, the only differences were elevated sodium and decreased secretory IgA levels in whole saliva. The reduction in secretory IgA has been suggested as a risk factor for the increased occurrence of sinobronchial infections (Izutsu et al, 1983a). One study reporting elevated labial salivary sodium concentration had a high predictive value for chronic GVHD (Izutsu et al, 1983b).…”
Section: (B) Oral Presentationmentioning
confidence: 99%
“…9,10 Salivary gland involvement in GVHD is indicated by increased xerostomia, accompanied by decreased levels of salivary immunoglobulins and increased incidence of oral infections, 11-13 a change in saliva composition, and histopathological changes in the labial minor salivary glands. [9][10][11]13 These pathological changes resemble the alterations observed in a Sjögren-like syndrome. 5,6 The significant involvement of salivary glands in the disease gained further support recently when lymphocyte infiltration into the major salivary gland in murine models of both acute and chronic GVHD (cGVHD) and in patients who clinically suffered from xerostomia, 7,14,15 was demonstrated.…”
mentioning
confidence: 92%