Disorders of collagen

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00012-7

Cited by 11 publications

(9 citation statements)

References 1,158 publications

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“…6a,b). However, presence of lichenoid infiltrates in early genital LS has been acknowledged by many investigators, 4,5,23–28 and it is possible that lichenoid interface dermatitis is a fore runner in the pathogenesis of LS, which may later evolve into vacuolar interface dermatitis. Linear studies with repeated histologic examinations are needed to prove this point.…”

Section: Discussionmentioning

confidence: 99%

Lichen sclerosus of lips: a clinical and histopathologic study of 27 cases

Attili¹,

Attili

2010

Int J Dermatology

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Lip LS is far less symptomatic and destructive with limited dermal sclerosis compared with genital LS. Greater awareness and histologic assessment are essential for diagnosis because of the misleading vitiligoid appearance. "Vitiligoid LS" a superficial variant proposed by Borda can be aptly applied to lip LS. Dermatologists need to be aware of this rarely reported manifestation of LS as it adds to the spectrum of oral lichenoid lesions and lichenoid dysplasia, which are suspected to have a malignant potential.

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Section: Discussionmentioning

confidence: 99%

Lichen sclerosus of lips: a clinical and histopathologic study of 27 cases

Attili¹,

Attili

2010

Int J Dermatology

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“…Curiously, none of the major dermatopathology textbooks or even a definitive tome on inflammatory skin disorders mentions perineural inflammation as a histopathologic feature of scleroderma/morphea. Given the fact that cutaneous nerves tend to travel along blood vessels, the validity of perineural inflammation might be critically questioned.…”

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confidence: 99%

Perineural inflammation in morphea (localized scleroderma): systematic characterization of a poorly recognized but potentially useful histopathological feature

2013

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The association between morphea and perineural inflammation has been reported sporadically but never studied systematically. To assess the prevalence and nature of perineural inflammation in various clinicopathologic stages of morphea and a cohort of other inflammatory dermatoses, 80 morphea and 36 control skin biopsies were studied using hematoxylin/eosin and S100 stains. Perineural inflammation was semiquantitatively analyzed (scored), which along with the pattern (concentric vs. marginal) and cellular composition was compared in the two groups. Perineural inflammation was identified in 84% and 61% of morphea and control cases, respectively. Examination of only routinely stained sections could still detect this feature in 58% of morphea and 33% of control biopsies. Mean perineural inflammation score in morphea (0.65) was significantly higher than in the control group (0.23) (p < 0.0001) and the inflammation tended to show a concentric pattern with plasma cell neurotropism. Intraneural inflammation was limited to four morphea cases. Although perineural inflammation is common in morphea, it is not unusual to find this feature in other inflammatory conditions. Nevertheless, perineural inflammation can serve as an important diagnostic adjunct in difficult cases of morphea if one considers its greater intensity, predominantly concentric pattern and the tendency to show plasma cell neurotropism.

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“…Previous studies suggest that collagen type III/I ratio plays an important role in wound healing [22,[24][25][26] (Figure 6a). In this study, the results demonstrated that type I collagen fibrils were the major components in ECM underlying epidermis in normal skin of Fraser's dolphin, mainly existing in the papillary dermis and reticular dermis demonstrated by trichrome, Herovici's and IHC staining.…”

Section: Discussionmentioning

confidence: 77%

“…During the wound healing process, type III collagens increase in the early stages of wound healing, and then type I collagen increases later in the remodeling phase in human skin. It is noteworthy that the collagen type III/I ratio in fetuses is higher than in adults [25,26], both in normal skin and recovered skin, and type III collagen remains the main subtype after wounding. The high level of collagen type III may influence the ECM organization and tissue stress.…”

Section: Introductionmentioning

confidence: 97%

Histopathological Study on Collagen in Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei)

Liu

Wang

et al. 2023

Animals

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Fraser’s dolphins (Lagenodelphis hosei) possess great healing abilities. Their skin composition can be restored after wounding, including collagen spacing, orientation, and bundle thickness. However, it remains unclear how collagens are involved in the wound-healing process and eventually regain normality in Fraser’s dolphins. Learned from the other two scarless healing animals, changes in type III/I collagen composition are believed to modulate the wound healing process and influence the scarring or scarless fate determination in human fetal skin and spiny mouse skin. In the current study, Herovici’s, trichrome, and immunofluorescence staining were used on normal and wounded skin samples in Fraser’s dolphins. The results suggested that type I collagens were the main type of collagens in the normal skin of Fraser’s dolphins, while type III collagens were barely seen. During the wound healing process, type III collagens showed at early wound healing stages, and type I collagen increased in the mature healed wound. In an early healed wound, collagens were organized in a parallel manner, showing a transient hypertrophic-like scar, and eventually restored to normal collagen configuration and adipocyte distribution in the mature healed wound. The remarkable ability to remove excessive collagens merits further investigation to provide new insights into clinical wound management.

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Disorders of collagen

Cited by 11 publications

References 1,158 publications

Lichen sclerosus of lips: a clinical and histopathologic study of 27 cases

Lichen sclerosus of lips: a clinical and histopathologic study of 27 cases

Perineural inflammation in morphea (localized scleroderma): systematic characterization of a poorly recognized but potentially useful histopathological feature

Histopathological Study on Collagen in Full-Thickness Wound Healing in Fraser’s Dolphins (Lagenodelphis hosei)

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