Disorders of Erythropoiesis, Granulopoiesis and Thrombopoiesis

doi:10.1002/9781119398929.ch8

Bone Marrow Pathology 2019

DOI: 10.1002/9781119398929.ch8

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Disorders of Erythropoiesis, Granulopoiesis and Thrombopoiesis

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2022

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Pancytopenia Due to Vitamin B12 and Folic Acid Deficiency—A Case Report

Depuis¹,

Gatineau-Sailliant²,

Ketelslegers³

et al. 2022

Pediatric Reports

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We report a case of severe pancytopenia in a 15-year-old patient due to a severe deficiency in vitamin B12 and folic acid, probably of nutritional origin. The clinical and biological course was favorable after vitamin supplementation. With this case, we discuss the diagnostic approach of pancytopenia with megaloblastic anemia in children and adolescents, as well as the mechanisms involved in vitamin B12 and B9 deficiency. Hypovitaminosis B12 is known in its severe form but its diagnosis is often made difficult by insidious signs and symptoms. Traditional intramuscular replacement therapy has now proven to be effective orally. The clinical manifestations of folic acid deficiency are relatively similar to those of vitamin B12 deficiency, reflecting their intricate co-enzymatic functions. Its supplementation is administered orally.

show abstract

Pancytopenia Due to Vitamin B12 and Folic Acid Deficiency—A Case Report

Depuis¹,

Gatineau-Sailliant²,

Ketelslegers³

et al. 2022

Pediatric Reports

View full text Add to dashboard Cite

show abstract

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Disorders of Erythropoiesis, Granulopoiesis and Thrombopoiesis

Cited by 1 publication

References 154 publications

Pancytopenia Due to Vitamin B12 and Folic Acid Deficiency—A Case Report

Pancytopenia Due to Vitamin B12 and Folic Acid Deficiency—A Case Report

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