Disorders of magnesium metabolism in epilepsy

Canelas, Horacio M.; Assis, Luís Marques de; Jorge, F.E.

doi:10.1136/jnnp.28.4.378

Cited by 16 publications

(5 citation statements)

References 20 publications

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“…It was observed in present study that mean magnesium level was significantly less amongst cases within 24 hours of seizures (1.47±0.50 mg/dl) and as the duration since seizure onset increased, mean magnesium level increased as evidenced by previous studies in which Magnesium levels decreased in patients with seizure disorders and the mean values were lower when time elapsed since onset of seizure is shorter thus confirming the possible role of magnesium in the pathophysiology of seizures. 3 Similar findings were reported by Horacio M et al 7 where magnesium level was lower when time elapsed after convulsion was shorter. Thus, following acute attack of seizure, serum magnesium tends to normalize with the time.…”

Section: Discussionsupporting

confidence: 77%

Association of serum magnesium levels with seizure disorder; experience from central India

Khare,

Jain,

Bhatnagar

et al. 2023

PJMS

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Magnesium is the fourth most abundant cation in the body. It has several functions in the human body including its role as a cofactor for more than 300 enzymatic reactions. Mg is a potential modulator of seizure activity because of its ability to antagonize the excitatory calcium influx through the N-methyl-D-aspartate receptor. Low magnesium levels in people with refractory epilepsy can increase the frequency of seizures. Hence in our study we aim to study the association of serum magnesium levels with seizure disorders and compare it with matched controls. In our study 154 adult individuals were included with seizure patients to control ratio of 1:1. Serum Magnesium levels was estimated in all individuals and levels were compared between patients of seizure disorder and healthy controls. Mean serum magnesium level was significantly lower in patients of seizure disorder as compared to controls (p<0.01). We, also observed significantly lower calcium level amongst cases as compared to controls (p<0.05). The mean magnesium level within 24 hours of seizures was 1.47±0.50 mg/dl whereas as the duration since seizures increased, mean magnesium level increased. In our study we found significant association between seizures and serum magnesium levels, as low magnesium has been implicated in refractory seizures which are resistant to anti-epileptic drugs and magnesium supplementation in such patients may result in decrease in number of anti-epileptic drugs and better control of seizures.

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Section: Discussionsupporting

confidence: 77%

Association of serum magnesium levels with seizure disorder; experience from central India

Khare,

Jain,

Bhatnagar

et al. 2023

PJMS

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“…Magnesium is the fourth most common cation in our body, the second most common intracellular cation and the most common intracellular divalent cation. 2 The human body contains around 25 g of magnesium. 3 Magnesium is necessary for the functioning of over 300 enzymes in human, 4 with 90% of total body magnesium being contained in the muscles and bones (~27% and ~63%, respectively), 90% of which is bound and with only 10% being free.…”

Section: Magnesium In Human Biologymentioning

confidence: 99%

“… Seizures 215 (overexcitation of the nervous system (nerve cells), which are more likely to fire due to a reduced electric potential difference between the outer and inner surfaces of the membrane). 2 Sudden cardiac death. Tachycardia.…”

Section: Clinical Signs Of Magnesium Deficiencymentioning

confidence: 99%

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis

2018

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Because serum magnesium does not reflect intracellular magnesium, the latter making up more than 99% of total body magnesium, most cases of magnesium deficiency are undiagnosed. Furthermore, because of chronic diseases, medications, decreases in food crop magnesium contents, and the availability of refined and processed foods, the vast majority of people in modern societies are at risk for magnesium deficiency. Certain individuals will need to supplement with magnesium in order to prevent suboptimal magnesium deficiency, especially if trying to obtain an optimal magnesium status to prevent chronic disease. Subclinical magnesium deficiency increases the risk of numerous types of cardiovascular disease, costs nations around the world an incalculable amount of healthcare costs and suffering, and should be considered a public health crisis. That an easy, cost-effective strategy exists to prevent and treat subclinical magnesium deficiency should provide an urgent call to action.

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“…Furthermore, although Mg2+ has been used to suppress seizures (Storchheim, 1993;Pritchard et al, 1984;Dinsdale, 1988), such effects are controversial (Wilson and Vulcano, 1984;Donaldson, 1986;Kaplan et al, 1988). Disturbance of [Mg2+I has been observed in serum or cerebrospinal fluid (CSF) of epileptic patients, but the differences rarely exceeded the physiologic ranges (Hirschfelder and Haury, 1938;Canelas et al, 1965;Breyer and Kanig, 1970;Begna et al 1985;Venkataraman et al, 1987).…”

mentioning

confidence: 99%

Extracellular Magnesium and Anticonvulsant Effects of Valproate in Young Rat Hippocampus

et al. 1995

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Extracellular field potential recordings were made in CA3 subfield of hippocampal slices from rats aged 11-22 days. In these experiments, we analyzed the effects induced by modifying [Mg2+] in the medium (1 or 2 mM) on (a) 4-aminopyridine (4-AP, 50 microM)-induced synchronous events (including ictal- and interictal-like epileptiform discharges as well as gamma-aminobutyric acid (GABA)-mediated potentials), and (b) the changes induced by the antiepileptic drug (AED) valproate (VPA 2 mM) on such activities. Changing [Mg2+] from 1 to 2 mM induced age-dependent effects consisting of reduction in rate of occurrence of ictal-like discharges at 11-13 days (55% reduction, p < 0.005) and 14-16 days (46% reduction, p < 0.025) postpartum. At any age, the rate of occurrence and the amplitude of the GABA-mediated synchronous potentials tended to decrease in 1 mM [Mg2+]. Similar effects were noted when changes in [Mg2+] were made during continuous application of the competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor DL-2-amino-5-phosphonovalerate (APV 50 microM). As previously reported, interictal and ictal discharges were blocked by addition of VPA to medium containing 2 mM [Mg2+]. Such an effect was not observed when [Mg2+] was decreased to 1 mM. In 1 mM, but not in 2 mM [Mg2+], VPA increased the amplitude of GABA-mediated synchronous potentials. Our results indicate that [Mg2+] plays a role in modulating occurrence of 4-AP-induced ictal activity and that it can influence the effects of VPA in this in vitro model of epileptogenesis.(ABSTRACT TRUNCATED AT 250 WORDS)

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Disorders of magnesium metabolism in epilepsy

Cited by 16 publications

References 20 publications

Association of serum magnesium levels with seizure disorder; experience from central India

Association of serum magnesium levels with seizure disorder; experience from central India

Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis

Extracellular Magnesium and Anticonvulsant Effects of Valproate in Young Rat Hippocampus

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