Disorders of Peripheral Nerves

Katirji, Bashar; Koontz, None Daniel

doi:10.1016/b978-1-4377-0434-1.00101-8

Cited by 19 publications

(20 citation statements)

References 496 publications

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“…We found male preponderance with male-to-female ratio of 1.72:1 and this corresponds with previous studies. 1,12 The GBS is considered as a sporadic illness, without a seasonal cluster. 1,15 In our study, occurrence was throughout the year, but >50% cases clustered between months of January and April.…”

Section: Discussionmentioning

confidence: 99%

“…Guillain-Barré syndrome is an acute inflammatory polyneuropathy with an incidence of 0.6 to 1.5/100,000, diagnosis being based on a set of defined clinical and laboratory criteria. 1,2 Multifocal segmental demyelination is the main underlying pathology of the disease. 3 in both upper and lower limbs on both sides so that the score ranged from 60 (normal) to 0 (quadriplegic) and by the GBS disability score (0 to 6) advocated by Hughes et al 8 Improvement was measured in terms of decrease in GB disability Score (GDS) by more than 1.…”

Section: Introductionmentioning

confidence: 99%

“…Based on clinical features, etiology, pathologic and electrophysiologic studies, GBS may be subclassified into several forms like acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor-sensory axonal neuropathy (AMSAN), acute motor axonal neuropathy (AMAN), Miller Fisher syndrome (MFS), and some other rare variants. 1,4 The GBS has an unpredictable course, with a mortality of 5 to 10%. 1 As compared with the West, reports from India seem to indicate increased mortality, and overall, a more fulminant form of the disease.…”

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confidence: 99%

“…1,4 The GBS has an unpredictable course, with a mortality of 5 to 10%. 1 As compared with the West, reports from India seem to indicate increased mortality, and overall, a more fulminant form of the disease. 5,6 Intravenous immunoglobulin and PE are effective treatments in GBS.…”

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confidence: 99%

“…5,6 Intravenous immunoglobulin and PE are effective treatments in GBS. 1 Several conflicting reports have been published regarding role of steroids in GBS. One study revealed the beneficial effect of a combination of IVIG with methylprednisolone, while another recently published study refuted any beneficial effect of addition of methylprednisolone to IVIG.…”

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confidence: 99%

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Guillain–Barré Syndrome: Profile of 120 Patients with respect to Response to Various Modalities of Treatment

Chafale¹,

Pandit²,

Lahoti³

et al. 2018

Indian Journal of Physical Medicine and Rehabilitation

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Introduction: Guillain-Barré Syndrome (GBS) is an inflammatory polyradiculoneuropathy with varied clinical manifestation and often dismal prognosis if not promptly treated. Recommended treatment modalities [intravenous immunoglobulin (IVIG) and plasma exchange (PE)] are costly and the role of steroids is controversial. Materials and methods:In this study, we reviewed the clinical and laboratory findings of consecutive patients with GBS (n = 120) and explored factors associated with outcome. We also compared response to different modalities of treatment including steroids. Results:There was no significant difference between the treatment outcomes of IVIG and PE and we found a nonsignificant trend toward improvement with intravenous (IV) steroid. We observed 4.17% mortality and most common cause of death was respiratory failure. Conclusion:Increasing age, delay in starting treatment, early peak disability, autonomic dysfunction, bulbar weakness, and reduced compound muscle action potential (CMAP) were associated with a poorer outcome. Group of patients treated with IVIG and plasmapheresis showed more improvement than the IV methylprednisolone group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Guillain–Barré Syndrome: Profile of 120 Patients with respect to Response to Various Modalities of Treatment

Chafale¹,

Pandit²,

Lahoti³

et al. 2018

Indian Journal of Physical Medicine and Rehabilitation

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Paraproteinemic neuropathies

2014

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The paraproteinemias are a heterogeneous group of disorders in which monoclonal plasma cells cause the proliferation of monoclonal proteins. They are of importance to clinicians because they often occur in association with neuropathies. Neurologists play a particularly important role when the neuropathy is the presenting feature, in which case they may uncover clinical, laboratory, radiologic, electrodiagnostic, or biopsy findings that lead to identification of the underlying paraproteinemia. The frequency of neuropathies in these patients, and the extent to which such neuropathies dominate the clinical picture, varies significantly between the different paraproteinemias. Treatments may be aimed specifically at the neuropathy, or against the underlying hematologic disorder. In all patients with paraproteinemias, the neurologist can work collaboratively with the hematologist to formulate therapeutic plans and goals and can provide follow-up and monitoring to determine the response of the neuropathy to treatment.

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Sleep, Breathing, and Neurologic Disorders

Chokroverty

Provini

2017

Sleep Disorders Medicine

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Disorders of Peripheral Nerves

Cited by 19 publications

References 496 publications

Guillain–Barré Syndrome: Profile of 120 Patients with respect to Response to Various Modalities of Treatment

Guillain–Barré Syndrome: Profile of 120 Patients with respect to Response to Various Modalities of Treatment

Paraproteinemic neuropathies

Sleep, Breathing, and Neurologic Disorders

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