Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Abstract

Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte -melanocyte unit, or as with the synapses of the neurological system. There are other roles, biochemical and mechanical, of melanocyte. Management that is inclusive of a maximally holistic approach justifies the use of diverse herbals, yoga and concern for cultural awareness provided by integrated medicine. Vitiligo provides a model which demonstrates that Ayurveda has a richer view of its presentations, possibly a stronger line on its pathogenesis, and a huge range of herbals, many now backed by studies from ethnobotanical laboratories, awaiting research into the many possible mechanisms by which they may act in the wide and complex field of melanocyte biochemistry.

Piebaldism in To Balo, South Sulawesi: Brief Report and Literature Review

“…The pattern of patches in To Balo almost similarly in all cases, it is symmetrical depigmentation, with a white forelock, but the pattern in the trunk, dorsal, and ventral in To Balo. It is rarely different from cases of piebaldism in someplace, were Xhosa tribal group in the Transkei, 300 km east of Cape Town (Arianayagam & Ryan, 2016). The distribution was alike in all, with symmetrical depigmentation involving the medial portion of the forehead, the chin, the ventral aspect of the chest, abdomen, and all extremities (Funkhouser et al, 2019;Park et al, 2002;Hazan, 2005).…”

Natural Melanogenesis Stimulator a Potential Tool for the Treatment of Hypopigmentation Disease

“…It is an autoimmune disease in which the pigmentinducing cells are injured. There is no therapy for vitiligo, however there are few therapies, including ultraviolet light, cosmetic cover-ups or corticosteroid creams medications [2]. Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors, tyrosinase, TRP-1, TRP-2 and MITF [1].…”