Disorders of Purine and Pyrimidine Metabolism

Seegmiller, J. Edwin

doi:10.1007/978-1-4684-3447-7_1

Cited by 15 publications

(13 citation statements)

References 239 publications

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“…The low plasma concentration (34–111 μ M ) (Catherine, 1995) and the potency of vitamin C to act as an pro‐oxidant (Chow, 1988) limit its contribution to the serum total antioxidant activity. Uric acid was suggested to have a biological role as an antioxidant contributing to the life span of primates with low urate oxidase activity (Seegmiller, 1979). However, serum concentrations of uric acid slightly higher than normal, due to its low solubility, are considered a risk factor of gout and heart disease (Reddy et al ., 1982).…”

Section: Discussionmentioning

confidence: 99%

Novel cardiac protective effects of urea: from shark to rat

Wang

Aouffen

et al. 1999

British J Pharmacology

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1 This study was carried out to investigate novel cardioprotective e ects of urea and the underlying mechanisms. The cardiac functions under oxidative stress were evaluated using Langendor perfused isolated heart. 2 Isolated dog®sh shark hearts tolerated the oxidative stress generated by electrolysis (10 mA, 1 min) of the perfusion solution (n=4), and also showed normal cardiac functions during postischaemia reperfusion (n=4). The high concentration of urea (350 mM) in the heart perfusate was indispensable for maintaining the normal cardiac functions of the shark heart. 3 Urea at 3 ± 300 mM (n=4 for each group) protected the isolated rat heart against both electrolysis-induced heart damage and post-ischaemia reperfusion-induced cardiac injury. 4 A concentration-dependent scavenging e ect of urea (3 ± 300 mM, n=4 for each group) against electrolysis-induced reactive oxygen species was also demonstrated in vitro. 5 Urea derivatives as hydroxyurea, dimethylurea, and thiourea had antioxidant cardioprotective e ect against the electrolysis-induced cardiac dysfunction of rat heart, but were not as e ective as urea in suppressing the post-ischaemia reperfusion injury. 6 Our results suggest that urea and its derivatives are potential antioxidant cardioprotective agents against oxidative stress-induced myocardium damage including the post-ischaemia reperfusioninduced injury.

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Section: Discussionmentioning

confidence: 99%

Novel cardiac protective effects of urea: from shark to rat

Wang

Aouffen

et al. 1999

British J Pharmacology

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“…Although gout is a kind of genetic disease, it is still closely related to diet. High consumption of purine in food will result in increasing levels of serum uric acid and 50% gout morbidity, while a lower‐purine diet can reduce blood uric acid levels and relieve symptoms of gout…”

Section: Introductionmentioning

confidence: 99%

Determination of four different purines and their content change in seafood by high-performance liquid chromatography

Sui

et al. 2016

J. Sci. Food Agric.

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“…Most patients with partial deficiency of HPRT enzyme activity demonstrate an increased rate of uric acid synthesis, gout appearing at an early age, and uric acid nephrolithiasis. Neurological dysfunction, however, has been absent or mild and has been unlike neurological manifestations of patients with the Lesch-Nyhan syndrome, suggesting that it may be unrelated to the deficiency of HPRT (Kelley et al, 1969;Seegmiller et al, 1974). Kelley et al (1969) stated that as little as 1% of normal HPRT activity in peripheral erythrocytes of patients is correlated with no detectable neurological dysfunction.…”

Section: Resultsmentioning

confidence: 99%

Hyperuricaemia and choreoathetosis in a child without mental retardation or self‐mutilation — a new HPRT variant

Gottlieb

Nyhan²,

Bakay³

et al. 1981

J of Inher Metab Disea

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A thirteen‐year‐old boy is described who had uric acid nephrolithiasis, spasticity and choreoathetosis, but no self‐mutilation or mental retardation. Initial studies suggested the presence of the classic Lesch‐Nyhan enzymatic defect; study of the metabolism of [8‐14C]hypoxanthine and [8‐14C]guanine in intact fibroblasts and careful analysis of the data indicated that this was not the case. This child represents a newly identified variant of the HPRT locus.

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Disorders of Purine and Pyrimidine Metabolism

Cited by 15 publications

References 239 publications

Novel cardiac protective effects of urea: from shark to rat

Novel cardiac protective effects of urea: from shark to rat

Determination of four different purines and their content change in seafood by high-performance liquid chromatography

Hyperuricaemia and choreoathetosis in a child without mental retardation or self‐mutilation — a new HPRT variant

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