Disorders of the Body Mass

Donohoue, Patricia A.; Ali, Omar

doi:10.1016/b978-0-12-383834-6.00094-x

Cited by 1 publication

(1 citation statement)

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“…The N-terminal 26aa-signal peptide of the precursor POMC protein is cleaved during maturation, and the remaining 241aa region is further processed into several peptides in a tissue-specific manner ( Figure 2C). In the anterior pituitary, POMC gives rise to several bioactive peptides, which include a 16kDa N-terminal POMC fragment (also known as Pro-γ-MSH), a joining peptide (JP), ACTH and beta-lipotropin (β-LPH) [6] ( Figure 2D). Very low levels of POMC peptide and mRNA have also been identified in several extrapituitary sites, including the pancreas, stomach, appendix, kidney, testis, prostate, placenta, skin, adipose tissue, skeletal muscle, lymph nodes, brain, adrenal and lung.…”

Section: Pituitary Specific Regulators Of Pro-opiomelanocortin Transcmentioning

confidence: 99%

Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription

Zhang

Heaney

2020

Cells

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The hypothalamic–pituitary–adrenal (HPA) axis plays a critical role in adaptive stress responses and maintaining organism homeostasis. The pituitary corticotroph is the central player in the HPA axis and is regulated by a plethora of hormonal and stress related factors that synergistically interact to activate and temper pro-opiomelanocortin (POMC) transcription, to either increase or decrease adrenocorticotropic hormone (ACTH) production and secretion as needed. Nuclear receptors are a family of highly conserved transcription factors that can also be induced by various physiologic signals, and they mediate their responses via multiple targets to regulate metabolism and homeostasis. In this review, we summarize the modulatory roles of nuclear receptors on pituitary corticotroph cell POMC transcription, describe the unique and complex role these factors play in hypothalamic–pituitary–adrenal axis (HPA) regulation and discuss potential therapeutic targets in disease states.

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Section: Pituitary Specific Regulators Of Pro-opiomelanocortin Transcmentioning

confidence: 99%