Disorders of the Immune System

Fischbein, Alf; Tarcher, Alyce Bezman

doi:10.1007/978-1-4899-2447-6_23

Cited by 2 publications

(1 citation statement)

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“…After stimulation, the spleen can differentiate a large number of T and B lymphocytes to participate in the body's immunity. Therefore, the changes of spleen and thymus quality can reflect the changes of the number of lymphocytes in the body and thus indirectly reflect the immune response level of the body [ 35 , 36 ]. Our current results suggest that the administration of COP1 can effectively enhance thymus and spleen indicators ( p < 0.01), suggesting that COP1 may enhance the host immune system despite promoting immune organs.…”

Section: Discussionmentioning

confidence: 99%

Chimonanthus nitens Oliv Polysaccharides Modulate Immunity and Gut Microbiota in Immunocompromised Mice

Zhang

Tang

Cai

et al. 2023

Oxidative Medicine and Cellular Longevity

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To investigate the immunomodulatory activities of Chimonanthus nitens Oliv polysaccharides (COP1), an immunosuppressive mouse model was generated by cyclophosphamide (CY) administration and then treated with COP1. The results demonstrated that COP1 ameliorated the body weight and immune organ (spleen and thymus) index of mice and improved the pathological changes of the spleen and ileum induced by CY. COP1 strongly stimulated the production of inflammatory cytokines (IL-10, IL-12, IL-17, IL-1β, and TNF-α) of the spleen and ileum by promoting the mRNA expressions. Furthermore, COP1 had immunomodulatory activity by increasing several transcription factors (JNK, ERK, and P38) in the mitogen-activated protein kinase (MAPK) signaling pathway. Related to the above immune stimulatory effects, COP1 positively affected the production of short-chain fatty acids (SCFAs) and the expression of ileum tight junction (TJ) protein (ZO-1, Occludin-1, and Claudin-1), upregulated the level of secretory immunoglobulin A (SIgA) in the ileum and microbiota diversity and composition, and improved intestinal barrier function. This study suggests that COP1 may provide an alternative strategy for alleviating chemotherapy-induced immunosuppression.

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Section: Discussionmentioning

confidence: 99%