Disorders of Transepidermal Elimination: Part 1

Woo, Thomas Y.; Rasmussen, James E.

doi:10.1111/j.1365-4362.1985.tb05781.x

Cited by 43 publications

(54 citation statements)

References 75 publications

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“…Micro-lesions shown here may not be sectioned across the right plane indicating the nominal lesion depths; optical magnification: 10Â. become activated after CO 2 irradiation [32,33]. Eventually, the excavated dermal tissue was replaced with new collagen in the natural haphazard orientation (Fig.…”

Section: Discussionmentioning

confidence: 99%

In vivo histological evaluation of a novel ablative fractional resurfacing device

et al. 2007

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Background and Objectives: A novel carbon dioxide (CO 2 ) laser device employing ablative fractional resurfacing was tested on human skin in vivo for the first time. Study Design/Materials and Methods: An investigational 30 W, 10.6 mm CO 2 laser system was focused to a 1/e 2 spot size of 120 mm to generate an array of microscopic treatment zones (MTZ) in human forearm skin. A range of pulse energies between 5 and 40 mJ was tested and lesion dimensions were assessed histologically using hematoxylin & eosin. Wound healing of the MTZ's was assessed immediately-, 2-day, 7-day, 1-month, and 3-month post treatment. The role of heat shock proteins was examined by immunohistochemistry. Results: The investigational CO 2 laser system created a microscopic pattern of ablative and thermal injury in human skin. The epidermis and part of the dermis demonstrated columns of thermal coagulation that surrounded tapering ablative zones lined by a thin eschar layer. Changing the pulse energy from 5 to 30 mJ resulted in a greater than threefold increase in lesion depth and twofold increase in width. Expression of heat shock protein (hsp)72 was detected as early as 2 days post-treatment and diminished significantly by 3 months. In contrast, increased expression of hsp47 was first detected at 7 days and persisted at 3 months post-treatment. Conclusion: The thermal effects of a novel investigational ablative CO 2 laser system utilizing fractional resurfacing were characterized in human forearm skin. We confirmed our previous ex vivo findings and show for the first time invivo, that a controlled array of microscopic treatment zones of ablation and coagulation could be deposited in human skin by varying treatment pulse energy. Immunohistochemical studies of heat shock proteins revealed a persistent collagen remodeling response lasting at least 3 months. We successfully demonstrated the first in-vivo use of ablative fractional resurfacing (AFR TM ) treatment on human skin.

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Section: Discussionmentioning

confidence: 99%

In vivo histological evaluation of a novel ablative fractional resurfacing device

et al. 2007

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“…TE is best known for its ability to eliminate foreign bodies such as deep splinters or thorns, but it can also eliminate endogenous tissue, particularly if changed by e.g. inflammation, to make them behave like foreign bodies [24] . TE and chondrodermatitis nodularis helicis (CNH) are closely related lesions, characterized by a combination of chronic inflammation of unknown aetiology and an epidermal defect over the site, through which tissue components altered by the inflammation are extruded [18] .…”

Section: Discussionmentioning

confidence: 99%

“…Auricular ossification is a rare cause of petrified ear, and the diagnosis requires histological examination (see Table 1) in contrast to calcification (dystrophic, metastatic, iatrogenic or idiopathic), which is a more common cause of petrified ear (see Table 2). Trans-epidermal elimination (TE) is a process, by which a foreign body or a native constituent having undergone radical changes is eliminated from the skin surface [24,25] .…”

Section: Introductionmentioning

confidence: 99%

Petrified auricle with ectopic ossification and trans- epidermal elimination of bone sequester: A case story and review of the literature

Krogh

Kjeldsen²,

Christensen

2014

CRCP

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Petrified auricle is a clinical condition in which parts of one or both auricles become rigid and stony hard due to calcification or ossification of cartilage. Auricular ossification is a rare clinical entity. Transepidermal elimination is an intricate epidermal and dermal tissue response to foreign material. Here we report a case of a 62-year-old Greenland man, who developed unilateral ectopic ossification of upper pole helix cartilage of the auricle in combination with trans epidermal elimination of a small bone sequester, causing inflammation and painful ulceration.

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“…Representa aspecto essencial do grupo das assim chamadas dermatoses perfurantes, tais como doença de Kyrle, colagenose perfurante reativa, elastose perfurante serpiginosa, foliculite perfurante, bem como das secundárias à insuficiência renal crônica e diabetes mellitus. 13,14 A ET pode ser esporadicamente observada em condições tão diversas como granulomas não infecciosos, reações cutâneas liquenóides, deposição extracelular de substâncias, neoplasias e infecções. No que diz respeito ao último grupo, um número crescente de microrganismos vem sendo citado no contexto da ETEP, incluindo fungos, bacté-rias, protozoários e até mesmo clamídias.…”

Section: Discussionunclassified

Eliminação transepidérmica de parasitas na doença de Jorge Lobo

Miranda

Costa

Bittencourt³

et al. 2010

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS: A eliminação transepidérmica de parasitas (ETEP) tem sido pouco estudada na doença de Jorge Lobo. OBJETIVOS: Identificar aspectos morfológicos da ETEP na doença de Jorge Lobo. MÉTODOS: Recortes de biópsias de doença de Jorge Lobo emblocados em parafina foram corados pela hematoxilina-eosina e examinados. Considerou-se como ETEP, exclusivamente, a presença de parasitas em estruturas epidérmicas. RESULTADOS: Foram incluídas no estudo 40 biópsias de 37 pacientes (31 homens e seis mulheres, média de idade 51,03 anos, variação 29-80 anos) realizadas em um período de 37 anos , das quais foram obtidos 511 cortes (média de 12,77 cortes por caso, variação 2-39 cortes por caso). Observou-se ETEP em 110/511 (21,52%) e não se observou em 401/511 cortes (78,48%) (p < 0,0001). Em relação aos pacientes (37), em 15 se verificaram aspectos consistentes com ETEP (40,5%), ao passo que, em 22 deles (59,5%), isso não foi observado (p > 0,05). Os parasitas dispunham-se em infundíbulos hiperplásicos, formando catênulas, ou como unidades isoladas, associados ou não a células inflamatórias. CONCLUSÕES: Aspectos consistentes com ETEP, embora observados em número estatisticamente não significante de pacientes da amostra (p > 0,05), sugerem que, na doença de Jorge Lobo, o fenômeno, invariavelmente, ocorra através do epitélio infundibular. Estudos futuros serão necessários para avaliar sua eventual importância na epidemiologia da micose. Palavras-chave: Doença granulomatosa crônica; Micoses; Micoses/patologia; Pele Abstract: BACKGROUND: Few studies have focussed on the transepidermal elimination of parasites in Jorge Lobo's disease (lobomycosis). OBJECTIVE: To identify the morphological features of the transepidermal elimination of parasites in lobomycosis. METHODS: Sections were obtained from paraffin-embedded biopsy specimens of patients with lobomycosis and stained with hematoxylin-eosin for microscopic examination. Only the presence of parasites in epidermal structures was considered to constitute transepidermal elimination. RESULTS: Forty biopsies from 37 patients were included in the study (31 males and 6 females). The mean age of patients was 51.03 years (range 29-80 years). Biopsies performed over a period of 37 years were used, from which 511 sections were obtained (a mean of 12.77 sections per case; range 2-39 sections per case). Transepidermal elimination of parasites was found in 110/511 (21.52%) and was absent in 401/511 sections (78.48%) (p<0.0001). Features consistent with the phenomenon were found in 15/37 patients (40.5%) and were absent in 22/37 (59.5%) (p>0.05). Parasites in the epidermis were detected within hyperplastic infundibula, either connected in chains or as isolated units, associated or not with inflammatory cells. CONCLUSION: Features consistent with transepidermal elimination of parasites were found in a statistically nonsignificant number of patients in the sample (p>0.05), suggesting that in Jorge Lobo's disease, this phenomenon invariably occurs through the infundibular epithelium. Fut...

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Disorders of Transepidermal Elimination: Part 1

Cited by 43 publications

References 75 publications

In vivo histological evaluation of a novel ablative fractional resurfacing device

In vivo histological evaluation of a novel ablative fractional resurfacing device

Petrified auricle with ectopic ossification and trans- epidermal elimination of bone sequester: A case story and review of the literature

Eliminação transepidérmica de parasitas na doença de Jorge Lobo

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