Disorganization of Retinal Inner Layers as a Biomarker for Idiopathic Epiretinal Membrane After Macular Surgery—The DREAM Study

Zur, Dinah; Iglicki, Matías; Feldinger, Lital; Schwartz, Shulamit; Goldstein, Michaella; Loewenstein, Anat; Barak, Adiel

doi:10.1016/j.ajo.2018.08.037

Cited by 77 publications

(71 citation statements)

References 24 publications

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“…In conclusion, this current study confirms and adds to the report that has been published by our group previously in Ophthalmology (Zur et al. ,b). We demonstrated that certain OCT biomarkers can help to predict response to DEX implant in eyes with DME.…”

Section: Discussionsupporting

confidence: 93%

“…This novel finding adds one more biomarker to the list previously reported by our group (Zur et al. ,b). The presence of SRF, IS/OS continuity, absence of HRF and an attached vitreoretinal interface predict better visual outcome after treatment with DEX implant in eyes with DME.…”

Section: Discussionsupporting

confidence: 65%

“…The absence of DRIL was significantly associated with the presence of SRF which is known to be more commonly seen in acute DME (Zur et al. ,b). These findings might indicate DRIL as a sign of chronicity of macular oedema.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the authors of this study identified baseline spectral‐domain (SD)‐OCT measures which can serve as biomarkers for predicting visual outcome after treatment with DEX Implant (Zur et al. ,b). Sun et al.…”

Section: Introductionmentioning

confidence: 99%

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Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

Zur

Iglicki

Sala‐Puigdollers

et al. 2019

Acta Ophthalmologica

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Purpose To investigate disorganization of retinal inner layers (DRIL) as a biomarker in eyes with diabetic macular oedema (DME) treated by intravitreal dexamethasone (DEX) implant. Methods Multicentre, retrospective study including eyes with DME treated with DEX implant and follow‐up of 12 months after the first injection. OCT scans were evaluated for the presence of DRIL and other structural features. Best corrected visual acuity (BCVA) and central subfield thickness (CST) were recorded at baseline and at 2, 4, 6 and 12 months after treatment. Correlation between DRIL at baseline and outcomes after DEX treatment and the change in DRIL were analysed. Results A total of 177 eyes (177 patients; naïve, n = 131; refractory, n = 46) were included. Patients without DRIL at baseline gained significantly more vision and enjoyed greater reduction in CST over 12 months (both p = 0.03). DRIL at the boundary between the ganglion cell‐inner plexiform complex and inner nuclear layer improved in 48/64 eyes (75%, p < 0.001), while DRIL between the inner nuclear layer and outer plexiform layer improved in 27/77 eyes (35%, p = 0.004). Conclusions This is the first study to show that DEX implant has the potential to ameliorate DRIL. Patients without DRIL at baseline have a favourable outcome. DRIL may serve a robust biomarker in DME treated by DEX implant.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

Zur

Iglicki

Sala‐Puigdollers

et al. 2019

Acta Ophthalmologica

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“…In the past, a large number of studies [18][19][20][21] have focused on the changes in microstructure of fovea due to iERM in order to identify the anatomic changes associated with the vision recovery after surgery. This included the integrity of ellipsoid zone, the central macular thickness (CMT) and the photoreceptor outer segments.…”

Section: Discussionmentioning

confidence: 99%

A study analyzing macular microvasculature features after vitrectomy using OCT angiography in patients with idiopathic macular epiretinal membrane

et al. 2020

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Background: To evaluate postoperative changes in retinal capillary plexus and to assess contributing factors in postoperative visual improvement using optical coherence tomography angiography (OCT-A) in patients with idiopathic epiretinal membrane (iERM) post membrane removal. Methods: Patients scheduled for vitrectomy and membrane peel for iERM were enrolled. 35 subjects were included for this study. OCT-A was used to measure the FAZ related parameters and the superficial and deep capillary plexus layers using 3 mm × 3 mm scans. Measurements were taken before surgery and at every post-surgical follow-up. The unaffected fellow eyes were used as controls. Evaluated factors included: BCVA, vessel density (VD) and retinal thickness (RT) in five regions, FAZ area, FAZ perimeter (PERIM), acircularity index (AI) and foveal vessel density (FD). Results: Compared with the control group, the foveal vessel density (FVD) in superficial capillary plexus (SCP) was greater in the epi-retinal membrane group (P < 0.0001), whereas both groups had comparable parafoveal vessel density (PRVD) in SCP (p > 0.05). After surgery there was a reduction in the PRVD in SCP. The FVD in DCP increased and the PRVD in DCP decreased at baseline (p < 0.001). After surgery there was an increase in PRVD in DCP. By 6 months post-op, the PRVD had no statistically significant difference compared with the control group (p > 0.05). Dvalue of LogMAR BCVA was positively correlated with pre-op LogMAR BCVA (p < 0.0001), FVD in SCP (p < 0.001). It was negatively correlated with FAZ area (P < 0.001) and PERIM (P < 0.05). Conclusions: Vitrectomy and membrane removal led to the decrease of VD in SCP and the increase of PRVD in DCP. Patients with a more severe iERM may receive greater visual improvement with surgery. Trial registration: Trial registration number (TRN) and date of registration. ChiCTR2000031289, retrospectively registered, 2020.03.26.

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Optical Coherence Tomography of the Vitreoretinal Interface

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Disorganization of Retinal Inner Layers as a Biomarker for Idiopathic Epiretinal Membrane After Macular Surgery—The DREAM Study

Cited by 77 publications

References 24 publications

Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

Disorganization of retinal inner layers as a biomarker in patients with diabetic macular oedema treated with dexamethasone implant

A study analyzing macular microvasculature features after vitrectomy using OCT angiography in patients with idiopathic macular epiretinal membrane

Optical Coherence Tomography of the Vitreoretinal Interface

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