Disorganization of Retinal Inner Layers and the Importance of Setting Boundaries

Schmidt‐Erfurth, Ursula; Michl, Martin

doi:10.1001/jamaophthalmol.2018.4516

Cited by 14 publications

(9 citation statements)

References 8 publications

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“…That strengthens the fact that as long as we performed appropriate statistical analysis, the data we detected in the current study were significant. Another limitation of the current study is that there is controversy regarding the inter-observer difference in DRIL evaluation 19 . To evaluate DRIL objectively, an automated detection system of DRIL should be developed in future 20,21 .…”

Section: Discussionmentioning

confidence: 91%

Association between disorganization of retinal inner layers and visual acuity after proliferative diabetic retinopathy surgery

Ishibashi

Sakimoto

Shiraki

et al. 2019

Sci Rep

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We report to evaluate if disorganization of the retinal inner layers (DRIL) obtained by swept-source optical coherence tomography (SS-OCT) predicts the postoperative best-corrected visual acuity (BCVA) to treat proliferative diabetic retinopathy (PDR). Twenty-one eyes of 21 patients who underwent vitrectomy for PDR were studied retrospectively. BCVA and SS-OCT images were obtained until 6 months postoperatively. The associations between BCVA and SS-OCT parameters measured in a 1-mm central foveal area were evaluated. The DRIL length, external limiting membrane disruption, and ellipsoid zone (EZ) disruption 1 month postoperatively were associated positively with the postoperative logarithm of the minimum angle of resolution (logMAR) BCVA at 1, 3, and 6 months (1 month, p = 0.009, p = 0.013, p = 0.001; 3 months, p = 0.03, p = 0.021, p = 0.002; and 6 months, p = 0.021, p = 0.013, and p = 0.005, respectively). The eyes with a 500-µm or longer DRIL 1 month postoperatively (19%, 4/21 eyes) had significantly worse VA at 1, 3, and 6 months postoperatively (p = 0.007, p = 0.008, and p = 0.020, respectively). Multilinear regression analysis of all visits until 6 months postoperatively showed that the DRIL was correlated more significantly (p = 0.0004) with logMAR BCVA than the disrupted EZ length. The DRIL in the early postoperative period may predict the visual outcomes after treating PDR.

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Section: Discussionmentioning

confidence: 91%

Association between disorganization of retinal inner layers and visual acuity after proliferative diabetic retinopathy surgery

Ishibashi

Sakimoto

Shiraki

et al. 2019

Sci Rep

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“…[16][17][18][19][20][21][22][23] The relative predictive power of the imaging features on SD-OCT varies between studies, likely due to differences in measurement techniques, limited sample size, 6,7,11,24 selective focus on individual factors, 7-13, 16, 17 and reliance on retrospective data with variable treatment patterns, [7][8][9][10][11][12][13][14][15][16] resulting in controversy regarding the validity of these findings. 10,[25][26][27] To address these inconsistencies, we evaluated baseline SD-OCT characteristics in the prospective, phase 4, randomized, multi-center Study Evaluating Dosing Regimens for Treatment with Intravitreal Ranibizumab Injections in Subjects with Macular Edema following Retinal Vein Occlusion (SHORE) study. 28 During the two phase 3 clinical trials: Treatment of Macular Edema following Branch Retinal Vein Occlusion: Evaluation of Efficacy and Safety (BRAVO) and the Treatment of Macular Edema following Central Retinal Vein Occlusion: Evaluation of Efficacy and Safety (CRUISE) studies, 29,30 monthly treatment with 0.3mg or 0.5mg ranibizumab resulted in substantial best-corrected visual acuity (BCVA) gain at 6 months.…”

Section: Introductionmentioning

confidence: 99%

Spectral-Domain OCT Predictors of Visual Outcomes after Ranibizumab Treatment for Macular Edema Resulting from Retinal Vein Occlusion

Yiu

Welch

Wang

et al. 2020

Ophthalmology Retina

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Objective/Purpose: To evaluate spectral domain optical coherence tomography (SD-OCT) features associated with baseline vision and visual outcomes after 7 monthly ranibizumab doses in the prospective, multicenter Study Evaluating Dosing Regimens for Treatment with Intravitreal Ranibizumab Injections in Subjects with macular Edema following Retinal Vein Occlusion (SHORE). Design: Post-hoc analysis of prospective clinical trial dataSubjects/Participants/Controls: 202 participants in the 15-month, phase IV, SHORE study comparing monthly versus PRN (pro re nata, as-needed) ranibizumab after 7 monthly doses in eyes with retinal vein occlusions (RVO) with macular edema.Methods/Intervention/Testing: The baseline SD-OCT images were assessed for 1) central subfield thickness (CST), 2) presence of vitreomacular adhesion, vitreomacular traction, or epiretinal membrane, 3) presence, location, and amount of intraretinal or subretinal fluid (IRF or SRF), 4) presence, location, and amount of hyperreflective foci (HF), 5) disorganization of retinal inner layers (DRIL), and 6) disruption of external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ). Univariate and multivariable regression analyses were performed to evaluate the association of these features with baseline BCVA and change in BCVA after 7 initial monthly ranibizumab injections.Main Outcome Measure: Association of SD-OCT features with baseline BCVA and change in BCVA after 7 monthly ranibizumab injections.Results: Prior to therapy, worse baseline BCVA was associated with ERM presence (P=0.0045), thicker SRF (P=0.0006), larger size of intraretinal cysts (P=0.0015), as well as higher % of DRIL (P<0.0001), % ELM disruption (P<0.0001), % EZ disruption (P=0.0003), and % IZ disruption (P=0.0018). In multivariate models, only % ELM disruption independently impacted baseline

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“…An advantage of HF with their high reflectance is that they may be more suitable for automated detection and inclusion in prediction models than other, less quantifiable, biomarkers that have shown associations with treatment response, such as DRIL. 23 , 24 Moreover, the evaluation of en face OCT images instead of single B-scan could facilitate faster manual quantification of HF. 25 …”

Section: Discussionmentioning

confidence: 99%

Retinal Hyperreflective Foci in Type 1 Diabetes Mellitus

Schreur

Breuk

Venhuizen

et al. 2020

Retina

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Disorganization of Retinal Inner Layers and the Importance of Setting Boundaries

Cited by 14 publications

References 8 publications

Association between disorganization of retinal inner layers and visual acuity after proliferative diabetic retinopathy surgery

Association between disorganization of retinal inner layers and visual acuity after proliferative diabetic retinopathy surgery

Spectral-Domain OCT Predictors of Visual Outcomes after Ranibizumab Treatment for Macular Edema Resulting from Retinal Vein Occlusion

Retinal Hyperreflective Foci in Type 1 Diabetes Mellitus

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