2018
DOI: 10.1167/iovs.18-24955
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Disorganization of Retinal Inner Layers (DRIL) and Neuroretinal Dysfunction in Early Diabetic Retinopathy

Abstract: PurposeTo elucidate the relationship between disorganization of retinal inner layers (DRILs) and retinal function in diabetic patients without diabetic retinopathy (DR) and with nonproliferative DR, but without diabetic macular edema (DME).MethodsFifty-seven participants with diabetes mellitus (DM) and 18 healthy controls underwent comprehensive ophthalmic examination, fundus photography, and spectral-domain optical coherence tomography. Scans of the fovea were evaluated for the presence of DRIL. Retinal funct… Show more

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Cited by 78 publications
(58 citation statements)
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“…A very recent work of Joltikov et al. (2018) elucidated the relationship between disorganization of retinal inner layers (DRILs) and retinal function in diabetic patients without diabetic retinopathy (DR) and with nonproliferative DR, but without diabetic macular edema (DME), using ETDRS visual acuity, the quick contrast sensitivity function, short-wavelength automated perimetry (SWAP), standard automated perimetry (SAP), and frequency doubling perimetry (FDP).…”
Section: Discussionmentioning
confidence: 99%
“…A very recent work of Joltikov et al. (2018) elucidated the relationship between disorganization of retinal inner layers (DRILs) and retinal function in diabetic patients without diabetic retinopathy (DR) and with nonproliferative DR, but without diabetic macular edema (DME), using ETDRS visual acuity, the quick contrast sensitivity function, short-wavelength automated perimetry (SWAP), standard automated perimetry (SAP), and frequency doubling perimetry (FDP).…”
Section: Discussionmentioning
confidence: 99%
“…This is validated from our results due to the discriminative capability and the p-values corresponding to INL in the comparison between controls and NPDR. Also, disorganization of retinal inner layers (DRILs) is associated with inner retinal thinning in patients with NoDR 10,21 . When comparing between NPDR and NoDR or controls, inner nuclear, outer plexiform, and ganglion cell layers were better predictors.…”
Section: Discussionmentioning
confidence: 99%
“…While pathologies such as subretinal fluid are known to alter the appearance of the retina, some other are strictly related with the layers (e.g. the disorganization of the retinal inner layers, or DRIL) [23]. Therefore, using retinal layer information is an appropriate way of incorporating anatomical knowledge into the model.…”
Section: A Retinal Oct Imagingmentioning
confidence: 99%