DISPACT trial: a randomized controlled trial to compare two different                 surgical techniques of DIStal PAnCreaTectomy — study rationale and design

Diener, MK; Knaebel, H. P.; Witte, Stefan; Rossion, Inga; Kieser, Meinhard; Büchler, M W; Seiler, C. M.

doi:10.1177/1740774508096140

Cited by 67 publications

(51 citation statements)

References 40 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] The majority of perioperative complications are not life-threatening, but they can prolong the hospital stay, increase costs, necessitate readmission, and delay adjuvant therapy. Thus, it is important to identify the predictive and intraoperative risk factors associated with operative morbidity after distal pancreatectomy (DP).…”

Section: Introductionmentioning

confidence: 99%

Can the physiologic ability and surgical stress (E-PASS) scoring system predict operative morbidity after distal pancreatectomy?

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Can the physiologic ability and surgical stress (E-PASS) scoring system predict operative morbidity after distal pancreatectomy?

et al. 2010

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“…One possible way to identify a better closure technique is to conduct a randomized clinical trial comparing the incidence of pancreatic fistula after hand-sewn versus stapler closure, and such a trial is now ongoing [14]. A randomized clinical trial can elucidate the superiority of one method over another; however, the overall incidence of pancreatic fistula is unlikely to decrease dramatically because the reported incidence of using either method is similarly high.…”

Section: Introductionmentioning

confidence: 99%

A Thick Pancreas Is a Risk Factor for Pancreatic Fistula after a Distal Pancreatectomy: Selection of the Closure Technique according to the Thickness

Eguchi¹,

Nagano²,

Tanemura³

et al. 2011

Dig Surg

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Background/Aims: Hand-sewn closures or stapler closures of the pancreatic remnant after a distal pancreatectomy have commonly been employed; however, the choice of technique in each patient depending on their clinical characteristics has not been discussed. Methods: Forty-eight patients who underwent a distal pancreatectomy at Osaka University Hospital between January 2007 and October 2009 were enrolled. A hand-sewn closure was planned during the 1st period (before June 2008, 26 consecutive patients), whereas a stapler closure was planned for the 2nd period (after June 2008, 22 consecutive patients). The incidence of pancreatic fistula and the patients’ characteristics were retrospectively investigated. Results: Seven patients (27%) developed a fistula in the hand-sewn group, while 5 (23%) developed a fistula in the stapler group (p = n.s.). Using logistic regression analysis for all patients, younger age and the thickness of the pancreatic remnant were identified as independent risk factors for pancreatic fistula. In the stapler group, 50% of patients with a thick pancreas developed a pancreatic fistula, while no patients with a thin pancreas developed one. Conclusion: Thick pancreas is one of the risk factors for pancreatic fistula after a distal pancreatectomy; however, a stapler closure seems to be suitable at least for thin pancreas.

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“…Das KKS-Netzwerk kooperiert mit dem Studienzentrum der Deutschen Gesellschaft für Chirurgie (SDGC) und ist dadurch mit dem Chirurgischen Studiennetzwerk ChirNet verbunden, einem vom BMBF geförderten Netzwerk chirurgischer Regionalzentren. Durch die Verflechtung mit dem ChirNet/SDGC verfügt das KKS-Netzwerk über eine besondere klinisch-methodische Expertise, die sich exemplarisch auch in der BMBF-geförderten DISPACTStudie widerspiegelt: Die in einem überwiegend onkologischen Patientenumfeld europaweit durchgeführte Studie vergleicht zwei verschiedene chirurgische Techniken und vereint chirurgische Qualitätssicherung und Daten-Monitoring [8]. …”

Section: Chirurgische Klinische Studien In Der Onkologieunclassified

Die Rolle der Koordinierungszentren für Klinische Studien (KKS) und des KKS-Netzwerks: Kompetenz für klinische Forschung

Ohmann¹,

Bruns²,

Wolff³

2010

Onkologie

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Das Netzwerk der Koordinierungszentren für Klinische Studien (KKS) umfasst 17 Institutionen, die bundesweit als akademisch verankerter Wissenschaftsdienstleister für Universitäten, Studiengruppen, die pharmazeutische und medizintechnische Industrie sowie weitere Auftraggeber, die im Umfeld klinischer Forschung tätig sind. Die KKS sichern die Good Clinical Practice (GCP)-konforme Planung, Durchführung und Auswertung klinischer Studien mit einer breiten Palette an Studiensupport. Ein indikationsspezifischer Schwerpunkt ist die Krebsforschung. Expertise in der onkologischen Forschung kann bundesweit und standortübergreifend abgerufen werden. Das KKS-Netzwerk kooperiert mit medizinischen Fachgesellschaften und anderen, auch europäischen Zusammenschlüssen in derzeit 20 Ländern und hat sich als belastbare Plattform für onkologische Studien profiliert.

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DISPACT trial: a randomized controlled trial to compare two different surgical techniques of DIStal PAnCreaTectomy — study rationale and design

Cited by 67 publications

References 40 publications

Can the physiologic ability and surgical stress (E-PASS) scoring system predict operative morbidity after distal pancreatectomy?

Can the physiologic ability and surgical stress (E-PASS) scoring system predict operative morbidity after distal pancreatectomy?

A Thick Pancreas Is a Risk Factor for Pancreatic Fistula after a Distal Pancreatectomy: Selection of the Closure Technique according to the Thickness

Die Rolle der Koordinierungszentren für Klinische Studien (KKS) und des KKS-Netzwerks: Kompetenz für klinische Forschung

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