Disparate Recruitment and Retention of Plasmacytoid Dendritic Cells to The Small Intestinal Mucosa between Young and Aged Mice

Hoffman, Rosemary A.; Huang, Shizhou; Chalasani, Geetha; Vallejo, Abbe N.

doi:10.14336/ad.2021.0119

Cited by 4 publications

(5 citation statements)

References 62 publications

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“…Interestingly, the functional alterations of pDCs in intestinal mucosa are age‐related 123 . The proportion and absolute amount of CD3 intestinal IE cells and pDC were much lower in elderly mice than in young animals, as validated by RT‐PCR.…”

Section: Gut‐associated Pdcs and Intestinal Immune Homeostasismentioning

confidence: 79%

“…Interestingly, the functional alterations of pDCs in intestinal mucosa are age‐related. 123 The proportion and absolute amount of CD3 intestinal IE cells and pDC were much lower in elderly mice than in young animals, as validated by RT‐PCR. CCL2 and IL‐6 expression was found to be elevated in aged mice, while CCL25 mRNA and protein levels were considerably lowered, which was consistent with a drop in the number of pDCs accompanied by a decrease in the number of cells migrating in the LPS‐treated model.…”

Section: Gut‐associated Pdcs and Intestinal Immune Homeostasismentioning

confidence: 80%

“…Before being stimulated by the pathogen, pre-pDCs migrate from BM to the intestinal epithelial layer, 49 and then into the lumen in the steady state. Expression of CCR7 (CD197) and CCR9 (CD199), as well as their corresponding ligands CCL19 (MIP-3β), CCL21 (6Ckine), and CCL25 (TECK), [121][122][123] can be able to present selfantigen and promote immune tolerance. 17 Multiple models have corroborated the development of pDC into particular tissues via homing receptors.…”

Section: Functional Location Of Pdcs In the Gutmentioning

confidence: 99%

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Current perspective on biological properties of plasmacytoid dendritic cells and dysfunction in gut

Guo,

He,

Xin

et al. 2023

Immunity Inflam & Disease

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Plasmacytoid dendritic cells (pDCs), a subtype of DC, possess unique developmental, morphological, and functional traits that have sparked much debate over the years whether they should be categorized as DCs. The digestive system has the greatest mucosal tissue overall, and the pDC therein is responsible for shaping the adaptive and innate immunity of the gastrointestinal tract, resisting pathogen invasion through generating type I interferons, presenting antigens, and participating in immunological responses. Therefore, its alleged importance in the gut has received a lot of attention in recent years, and a fresh functional overview is still required. Here, we summarize the current understanding of mouse and human pDCs, ranging from their formation and different qualities compared with related cell types to their functional characteristics in intestinal disorders, including colon cancer, infections, autoimmune diseases, and intestinal graft‐versus‐host disease. The purpose of this review is to convey our insights, demonstrate the limits of existing research, and lay a theoretical foundation for the rational development and use of pDCs in future clinical practice.

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Section: Gut‐associated Pdcs and Intestinal Immune Homeostasismentioning

confidence: 79%

Section: Gut‐associated Pdcs and Intestinal Immune Homeostasismentioning

confidence: 80%

Section: Functional Location Of Pdcs In the Gutmentioning

confidence: 99%

See 1 more Smart Citation

Current perspective on biological properties of plasmacytoid dendritic cells and dysfunction in gut

Guo,

He,

Xin

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

show abstract

“…Another study showed that the deficiency of Ercc1 (part of the Ercc1XPF endonuclidene enzyme, which is crucial for various DNA repair processes, especially in hematopoietic cells) impaired the repair of DNA damage, accelerated the increase of senescent cells and endogenous oxidative damage in various tissues in mice [ 110 ]. The absolute number of pDCs in the intestinal epithelium of aged mice was substantially reduced and the expression of the inflammatory chemokine CCL25 changed with age [ 111 ]. Moreover, senescence and SASP production in several organs were induced by the adoptive transfer of spleen cells from old WT mice to young mice, which considerably decreased longevity [ 112 ].…”

Section: Cellular Aging Biomarkersmentioning

confidence: 99%

Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review

2024

Aging dis

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The risk of developing chronic illnesses and disabilities is increasing with age. To predict and prevent aging, biomarkers relevant to the aging process must be identified. This paper reviews the known molecular, cellular, and physiological biomarkers of aging. Moreover, we discuss the currently available technologies for identifying these biomarkers, and their applications and potential in aging research. We hope that this review will stimulate further research and innovation in this emerging and fast-growing field.

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“…DCs are a member of innate immunity and play a critical role in the phagocytosis and release of inflammatory factors. They additionally play a unique role in bridging innate and adaptive immunity ( 109 ), owing to which these cells have been correlated in a wide range of diseases, including atherosclerosis, various cancers, and more recently, stroke ( 110 ). Accumulative evidence has revealed increased recruitment of DCs and their potential role in brain injury following stroke onset.…”

Section: Regulatory Role Of 17β-estradiol In Neuroinflammationmentioning

confidence: 99%

Immunomodulatory role of estrogen in ischemic stroke: neuroinflammation and effect of sex

Zhong¹,

Sun²,

Lü³

et al. 2023

Front. Immunol.

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Although estrogen is predominantly related to the maintenance of reproductive functioning in females, it mediates various physiological effects in nearly all tissues, especially the central nervous system. Clinical trials have revealed that estrogen, especially 17β-estradiol, can attenuate cerebral damage caused by an ischemic stroke. One mechanism underlying this effect of 17β-estradiol is by modulating the responses of immune cells, indicating its utility as a novel therapeutic strategy for ischemic stroke. The present review summarizes the effect of sex on ischemic stroke progression, the role of estrogen as an immunomodulator in immune reactions, and the potential clinical value of estrogen replacement therapy. The data presented here will help better understand the immunomodulatory function of estrogen and may provide a basis for its novel therapeutic use in ischemic stroke.

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Disparate Recruitment and Retention of Plasmacytoid Dendritic Cells to The Small Intestinal Mucosa between Young and Aged Mice

Cited by 4 publications

References 62 publications

Current perspective on biological properties of plasmacytoid dendritic cells and dysfunction in gut

Current perspective on biological properties of plasmacytoid dendritic cells and dysfunction in gut

Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review

Immunomodulatory role of estrogen in ischemic stroke: neuroinflammation and effect of sex

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