Disparities in Early-Onset Colorectal Cancer

Muller, Charles; Ihionkhan, Ehizokha O.; Stoffel, Elena M.; Kupfer, Sonia S.

doi:10.3390/cells10051018

Cited by 55 publications

(52 citation statements)

References 125 publications

(187 reference statements)

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“…There is a trend of increasing rates of early-onset cancer, defined as diagnosis before the age of 50. The observed younger median age of cancer diagnosis in BIPOC may be due young age structure in Latinos [ 95 ]; evidence suggests, however, that BIPOC individuals are experiencing a heavier burden of early-onset renal [ 5 ], lung [ 96 ], colorectal [ 97 ], and breast [ 98 ] cancers.…”

Section: Early-onset Cancer Disparitiesmentioning

confidence: 99%

Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences

Valencia

Gachupin

Molina

et al. 2022

IJERPH

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The objective of this article is to call for integrating biological pathways of social experiences in the concept model of cancer disparities and social determinants of health (SDH) fields. Black, Indigenous, and People of Color (BIPOC) populations experience more negative outcomes across the cancer continuum. Social conditions are instrumental in better understanding the contemporary and historical constructs that create these patterns of disparities. There is an equally important body of evidence that points to the ways that social conditions shape biological pathways. To date, these areas of research are, for the most part, separate. This paper calls for a bridging of these two areas of research to create new directions for the field of cancer disparities. We discuss inflammation, epigenetic changes, co-morbidities, and early onset as examples of the biological consequences of social conditions that BIPOC populations experience throughout their lifespan that may contribute to disproportionate tumorigenesis and tumor progression.

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Section: Early-onset Cancer Disparitiesmentioning

confidence: 99%

Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences

Valencia

Gachupin

Molina

et al. 2022

IJERPH

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show abstract

“…Familial CRC is the third and least well understood pattern [ 15 ]. A family history of CRC occurs in up to 25% of affected patients but the pattern is not consistent with those of the inherited syndromes [ 16 ]. Individuals from these families are more likely to develop CRC, although the risk is not as high as those with inherited syndromes [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Emerging roles for lncRNA-NEAT1 in colorectal cancer

et al. 2022

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Colorectal cancer (CRC) is the third cause of cancer death in the world that arises from the glandular and epithelial cells of the large intestine, during a series of genetic or epigenetic alternations. Recently, long non-coding RNAs (lncRNAs) has opened a separate window of research in molecular and translational medicine. Emerging evidence has supported that lncRNAs can regulate cell cycle of CRC cells. LncRNA NEAT1 has been verified to participate in colon cancer development and progression. NEAT1 as a competing endogenous RNA could suppress the expression of miRNAs, and then regulate molecules downstream of these miRNAs. In this review, we summarized emerging roles of NEAT1 in CRC cells.

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“…[11][12][13] Disparities in EOCRC incidence in the United States are exacerbated when geography is considered. 14 For example, disparities are apparent among residents of rural versus urban areas in both CRC risk factors and many social determinants of health (e.g., smoking, obesity, and health care access and utilization). Low rates of CRC screening have been associated with low socioeconomic status, low household income, lack of health insurance, and smoking, among other factors, likely contributing to the increasing disparity in EOCRC incidence in these populations.…”

mentioning

confidence: 99%

Early-Onset Colorectal Cancer Survival Differences and Potential Geographic Determinants Among Men and Women in Utah

Rogers

Korous

Brooks

et al. 2022

American Society of Clinical Oncology Educational Book

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By 2030, early-onset colorectal cancer (EOCRC) is expected to become the leading cancer-related cause of death for people age 20 to 49. To improve understanding of this phenomenon, we analyzed the geographic determinants of EOCRC in Utah by examining county-level incidence and mortality. We linked data from the Utah Population Database to the Utah Cancer Registry to identify residents (age 18–49) diagnosed with EOCRC between 2000 and 2020, and we used spatial empirical Bayes smoothing to determine county-level hotspots. We identified 1,867 EOCRC diagnoses (52.7% in male patients, 69.2% in non-Hispanic White patients). Ten counties (34%) were classified as hotspots, with high EOCRC incidence or mortality. Hotspot status was unrelated to incidence rates, but non-Hispanic ethnic-minority men (incidence rate ratio, 1.49; 95% CI, 1.15–1.91), Hispanic White men and women (incidence rate ratio, 2.24; 95% CI, 2.00–2.51), and Hispanic ethnic-minority men and women (incidence rate ratio, 4.59; 95% CI, 3.50–5.91) were more likely to be diagnosed with EOCRC. After adjustment for income and obesity, adults living in hotspots had a 31% higher hazard for death (HR, 1.31; 95% CI, 1.02–1.69). Survival was poorest for adults with a late-stage diagnosis living in hotspots (chi square (1) = 4.0; p = .045). Adults who were married or who had a life partner had a lower hazard for death than single adults (HR, 0.73; 95% CI, 0.58–0.92). The risk for EOCRC is elevated in 34% of Utah counties, warranting future research and interventions aimed at increasing screening and survival in the population age 18 to 49.

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Disparities in Early-Onset Colorectal Cancer

Cited by 55 publications

References 125 publications

Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences

Interrogating Patterns of Cancer Disparities by Expanding the Social Determinants of Health Framework to Include Biological Pathways of Social Experiences

Emerging roles for lncRNA-NEAT1 in colorectal cancer

Early-Onset Colorectal Cancer Survival Differences and Potential Geographic Determinants Among Men and Women in Utah

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