Disparities in insulin resistance between black and white adults in the United States: The role of lifespan stress exposure

Fuller‐Rowell, Thomas E.; Homandberg, Lydia K.; Curtis, Dorothy; Tsenkova, Vera K.; Williams, David R.; Ryff, Carol D.

doi:10.1016/j.psyneuen.2019.04.020

Cited by 25 publications

(19 citation statements)

References 48 publications

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“…Cortisol ( n Total = 5; n Significant = 2), BDNF ( n Total = 1; n Significant = 0), SICAM-1 n Total = 1; n Significant = 1), and insulin ( n Total = 1; n Significant = 1) were biomarkers used to measure nervous and endocrine system functionality when examining ACEs. Findings revealed that ACEs were associated with dysfunctional activity in these biomarkers (Carroll et al, 2013; Drury et al, 2014; Fuller-Rowell et al, 2019). Specifically, experiencing more ACEs was associated with reductions in cortisol reactivity (Peckins et al, 2012), BDNF (S. Kim et al, 2019), and SICAM-1 (Slopen et al, 2010) as well as a resistance to insulin in diabetic participants (Fuller-Rowell et al, 2019).…”

Section: Resultsmentioning

confidence: 98%

A Systematic Review of the Biological Correlates and Consequences of Childhood Maltreatment and Adverse Childhood Experiences

Cooke

Connolly

Boisvert

et al. 2021

Trauma, Violence, & Abuse

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Childhood maltreatment (CM) and adverse childhood experiences (ACEs) are two primary forms of interpersonal victimization that have been associated with a host of deleterious health outcomes. Studies over the past decade have begun to use a range of biologically informed methods to better understand the role biology plays in the relationship between CM, ACEs, and later life outcomes. This line of research has shown that both forms of victimization occur at sensitive periods of development, which can increase the likelihood of “getting under the skin” and influence health and behavior across the life course. This review examines the current state of knowledge on this hypothesis. One hundred and ninety-nine studies are included in this systematic review based on criteria that they be written in English, use a biologically informed method, and be conducted on samples of humans. Results reveal that latent additive genetic influences, biological system functioning captured by biomarkers, polygenic risk scores, and neurobiological factors are commonly associated with exposure and response to CM and ACEs. The implication of these findings for the existing body of research on early life victimization and recommendations for future research and policy are discussed.

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Section: Resultsmentioning

confidence: 98%

A Systematic Review of the Biological Correlates and Consequences of Childhood Maltreatment and Adverse Childhood Experiences

Cooke

Connolly

Boisvert

et al. 2021

Trauma, Violence, & Abuse

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“…Indeed, numerous studies have suggested different effects of IR across racial/ethnic groups. Postulated mechanisms are: varying basal insulin secretion levels, distribution of adiposity, genetics, environmental factors, and psychosocial stress [12][13][14].…”

Section: Discussionmentioning

confidence: 99%

Correlation between insulin-based and C-peptide based homeostatic model assessment of insulin resistance in adults without diabetes in a sub-Saharan African setting: a cross-sectional study

Tekoh

Mbono-Samba²,

Etoa-Etoga³

et al. 2022

BMC Res Notes

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Objective To assess the correlation between the insulin-based and C-peptide based HOMA-IR in the general population without diabetes in sub-Saharan Africa as well as to identify factors associated with IR. Results This was a cross-sectional study in urban settings in Yaoundé, Cameroon. We included 84 people with a body mass index (BMI) ≥ 18.5 Kg/m² and without diabetes (females: 72.6%; mean age: 37 years). IR was assessed using the following formulae: HOMA-IRINS = fasting insulin (mU/ml) x fasting plasma glucose (FPG) (mmol/L)/ 22.5; HOMA-IRCP1 = fasting C-peptide (mU/ml) x FPG (mmol/L)/ 22.5; and HOMA-IRCP2 = 1.5 + (FPG (mg/dl) x fasting C-peptide (ng/ml))/ 2800. Correlation (rho) between HOMA-IRINS and C-peptide based HOMA-IR was investigated using the Spearman rank test. The median (25th -75th percentiles) HOMA-IRINS, HOMA-IRCP1, and HOMA-IRCP2 were: 1.94 (1.36–3.50), 0.18 (0.11–0.27) and 9.91 (6.81–14.52), respectively. There was no correlation between the insulin-based and C-peptide-based HOMA-IR indices: rho = 0.043, p = 0.697. IR (HOMA-IRINS ≥ 2.8) was associated with obesity: A BMI ≥ 30 Kg/m² (adjusted odds ratio (aOR): 16.9, 95% confidence intervals (CI): 3.1–92.5) and being a student (aOR: 8.9, 95%CI: 2.1–38.2) were associated with IR.

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“…However, the mechanisms contributing to the progression of insulin resistance in Black women are not well-understood [ 7 , 10 , 11 ]. Ancestral genetic differences have been linked to insulin resistance in Black individuals [ 12 , 13 ], but the recognition of race as a social construct highlights social determinants of health as important mediators [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Differences in gut microbiome by insulin sensitivity status in Black and White women of the National Growth and Health Study (NGHS): A pilot study

et al. 2022

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The prevalence of overweight and obesity is greatest amongst Black women in the U.S., contributing to disproportionately higher type 2 diabetes prevalence compared to White women. Insulin resistance, independent of body mass index, tends to be greater in Black compared to White women, yet the mechanisms to explain these differences are not completely understood. The gut microbiome is implicated in the pathophysiology of obesity, insulin resistance and cardiometabolic disease. Only two studies have examined race differences in Black and White women, however none characterizing the gut microbiome based on insulin sensitivity by race and sex. Our objective was to determine if gut microbiome profiles differ between Black and White women and if so, determine if these race differences persisted when accounting for insulin sensitivity status. In a pilot cross-sectional analysis, we measured the relative abundance of bacteria in fecal samples collected from a subset of 168 Black (n = 94) and White (n = 74) women of the National Growth and Health Study (NGHS). We conducted analyses by self-identified race and by race plus insulin sensitivity status (e.g. insulin sensitive versus insulin resistant as determined by HOMA-IR). A greater proportion of Black women were classified as IR (50%) compared to White women (30%). Alpha diversity did not differ by race nor by race and insulin sensitivity status. Beta diversity at the family level was significantly different by race (p = 0.033) and by the combination of race plus insulin sensitivity (p = 0.038). Black women, regardless of insulin sensitivity, had a greater relative abundance of the phylum Actinobacteria (p = 0.003), compared to White women. There was an interaction between race and insulin sensitivity for Verrucomicrobia (p = 0.008), where among those with insulin resistance, Black women had four fold higher abundance than White women. At the family level, we observed significant interactions between race and insulin sensitivity for Lachnospiraceae (p = 0.007) and Clostridiales Family XIII (p = 0.01). Our findings suggest that the gut microbiome, particularly lower beta diversity and greater Actinobacteria, one of the most abundant species, may play an important role in driving cardiometabolic health disparities of Black women, indicating an influence of social and environmental factors on the gut microbiome.

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Disparities in insulin resistance between black and white adults in the United States: The role of lifespan stress exposure

Cited by 25 publications

References 48 publications

A Systematic Review of the Biological Correlates and Consequences of Childhood Maltreatment and Adverse Childhood Experiences

A Systematic Review of the Biological Correlates and Consequences of Childhood Maltreatment and Adverse Childhood Experiences

Correlation between insulin-based and C-peptide based homeostatic model assessment of insulin resistance in adults without diabetes in a sub-Saharan African setting: a cross-sectional study

Differences in gut microbiome by insulin sensitivity status in Black and White women of the National Growth and Health Study (NGHS): A pilot study

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