2021
DOI: 10.1002/cncr.33853
|View full text |Cite
|
Sign up to set email alerts
|

Disparities in phase 1 cancer clinical trial enrollment

Abstract: Background Phase 1 trials are increasingly important in the molecularly driven era of oncology, but few studies have examined phase 1 participation disparities. The authors of this study investigated factors associated with phase 1 versus phase 2/3 trial enrollment. Methods They authors conducted a cross‐sectional study using serial samples of patients age ≥18 years enrolling on cancer trials from October 2011 to November 2014 at an academic cancer center. They used univariable and multivariable logistic regre… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
21
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 26 publications
(21 citation statements)
references
References 22 publications
0
21
0
Order By: Relevance
“… 4 , 9 Similar disparities in phase 1 cancer clinical trial enrollment have been noted in studies conducted at single institutions. 10 …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“… 4 , 9 Similar disparities in phase 1 cancer clinical trial enrollment have been noted in studies conducted at single institutions. 10 …”
Section: Discussionmentioning
confidence: 99%
“…4,9 Similar disparities in phase 1 cancer clinical trial enrollment have been noted in studies conducted at single institutions. 10 When examining racial and ethnic disparities in clinical research, it is essential to acknowledge the harms that individuals of racial and ethnic minority groups have experienced at the hands of the US health care system, especially in the research setting. 11 These historical harms have led to mistrust of academic and research institutions and investigators, which is further exacerbated by current socioeconomic and health care system inequities.…”
Section: Discussionmentioning
confidence: 99%
“…These results withstood adjustments for important confounders such as age, sex, insurance status, marital status, income, cancer type, and travel distance. 20 Informed consent forms are often only available in the dominant language of a country and ethnic minorities with limited language proficiency will not be able to participate in trials. A focus on patient friendly recruitment material for trials may facilitate enrollment of participants with broader ethnic, educational, and socioeconomic backgrounds.…”
Section: Thoughtful Design Of Patient Information and Encouragement O...mentioning
confidence: 99%
“… 6 Populations served in health safety net settings with Medicaid insurance have lower rates of participation in cancer clinical trials, particularly among Black and Latino patients. 7 , 8 The Covid-19 pandemic has compounded the risk of delays in cancer diagnosis and treatment for underserved populations given higher rates of Covid-19 infection and job loss, increasing the disproportionate burden of care on clinicians and systems caring for populations in safety-net settings. 9 , 10 At the same time, safety net hospitals are trusted care settings with unique expertise in the population served including shared culture, language, illness understanding, and a history of adversity and collective action.…”
Section: Introductionmentioning
confidence: 99%