Background and purposeThere is conflicting evidence regarding whether physiciansâ clinical experience affects healthcare quality. Knowing whether an association exists and which dimensions of quality might be affected can help healthcare services close quality gaps by tailoring improvement initiatives according to physiciansâ clinical experience. Here, we present a systematised review that aims to assess the potential association between physiciansâ clinical experience and different dimensions of healthcare quality.MethodsWe conducted a systematised literature review, including the databases MEDLINE, Embase, PsycINFO and PubMed. The search strategy involved combining predefined terms that describe physiciansâ clinical experience with terms that describe different dimensions of healthcare quality (ie, safety, clinical effectiveness, patient-centredness, timeliness, efficiency and equity). We included relevant, original research published from June 2004 to November 2020.ResultsFifty-two studies reporting 63 evaluations of the association between physiciansâ clinical experience and healthcare quality were included in the final analysis. Overall, 27 (43%) evaluations found a positive or partially positive association between physiciansâ clinical experience and healthcare quality; 22 (35%) found no association; and 14 (22%) evaluations reported a negative or partially negative association. We found a proportional association between physiciansâ clinical experience and quality regarding outcome measures that reflect safety, particularly in the surgical fields. For other dimensions of quality, no firm evidence was found.ConclusionWe found no clear evidence of an association between measures of physiciansâ clinical experience and overall healthcare quality. For outcome measures related to safety, we found that physiciansâ clinical experience was proportional with safer care, particularly in surgical fields. Our findings support efforts to secure adequate training and supervision for early-career physicians regarding safety outcomes. Further research is needed to reveal the potential subgroups in which gaps in quality due to physiciansâ clinical experience might exist.