Disparity in actions of rosiglitazone against cisplatin-induced nephrotoxicity in female Sprague-Dawley rats

Curcumin Ameliorates Cisplatin-Induced Nephrotoxicity and Potentiates Its Anticancer Activity in SD Rats: Potential Role of Curcumin in Breast Cancer Chemotherapy

“…The complex spectrum of CIS nephrotoxicity includes DNA damage, tubular toxicity, and inflammation (Kumar et al, 2013c). The inflammation plays a central pathophysiological role in CIS associated nephrotoxicity, as CIS injection induces a cascade of inflammatory responses in the kidney through the release of several cytokines (TNF-α, IL-1β etc.)…”

“…and chemokines [MCP-1, macrophage inflammatory protein (MIP)-2 etc.]. TNF-α plays a significant role in the production of other inflammatory cytokines and chemokines and is a chief wrongdoer of the CIS-induced inflammatory renal injury (Deng et al, 2001; Ramesh and Reeves, 2002; Kumar et al, 2013c). Times and again, umpteen theories have been proposed for prevention of its nephrotoxicity but of little/no avail (Ueki et al, 2013).…”

“…The combination of CUR and α-tocopherol is renoprotective by inhibiting of NADPH oxidase (Palipoch et al, 2013). Former studies have urged that usage of rosiglitazone and CUR (anti-inflammatory agents) is safe and one of the key approaches to attenuate CIS-induced renotoxicity (Ueki et al, 2013; Kumar et al, 2013c). …”

Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague–Dawley rats

“…In this study, we found significantly high levels of antioxidant enzyme like, SOD, catalase and GSH in combined treated rats as compared to breast cancer rats. In fact amelioration of cisplatin nephrotoxicity by targeting inflammatory cascade NF-κB and TNF-α was significantly showed by Kumar et al [48] and Kuhad et al [49] by oxidative cascade. Likewise, anti-oxidant mechanism of NDGA may potentiate the cytotoxicity of cisplatin [50].…”

Pharmacological inhibition of NADPH oxidase protects against cisplatin induced nephrotoxicity in mice by two step mechanism

“…All combinatorial effects leads to reduced inflammation and cell death, thus protecting against cisplatin induced kidney injury . 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 suppressing the inflammatory response (Guerrero-Beltran et al, 2012;Kumar et al, 2013;Lee et al, 2006;Li et al, 2002;Ozkaya et al, 2010). Acetovanillone putatively inhibit Nox2 and ameliorated the immune response.…”